{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:26:31Z","timestamp":1789046791346,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009468","name":"Conseil R\u00e9gional Aquitaine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009468","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["end\u2010of\u2010thesis fellowship"],"award-info":[{"award-number":["end\u2010of\u2010thesis fellowship"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20180839586"],"award-info":[{"award-number":["DEQ20180839586"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["comit\u00e9 de Gironde"],"award-info":[{"award-number":["comit\u00e9 de Gironde"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["comit\u00e9 des Landes"],"award-info":[{"award-number":["comit\u00e9 des Landes"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO2014\u2010182"],"award-info":[{"award-number":["PLBIO2014\u2010182"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004793","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>\n                    Endometrial cancer is one of the main gynecological malignancies worldwide. Several studies highlight\n                    <jats:italic>ARHGAP35<\/jats:italic>\n                    as a significantly mutated gene in these tumors. It encodes for p190RhoGAP\u2010A (p190A), which is a major regulator of the small GTPase family of proteins.\n                    <jats:italic>ARHGAP5<\/jats:italic>\n                    is a paralog of\n                    <jats:italic>ARHGAP35<\/jats:italic>\n                    that encodes p190RhoGAP\u2010B (p190B). By analyzing human endometrial cancer samples, we found a co\u2010occurrence of mutations in\n                    <jats:italic>ARHGAP35<\/jats:italic>\n                    and\n                    <jats:italic>ARHGAP5<\/jats:italic>\n                    genes and reported that both are less expressed at the mRNA level in tumoral samples compared to healthy tissues. We then studied the impact of p190A\/B under\u2010expression in endometrial cancer and the relationship between the two paralogs. We generated CRISPR\/Cas9\u2010mediated HEC\u20101\u2010A knockout cells for p190A and p190B. We showed that removal of each paralog led to a similar actin remodeling phenotype with the formation of Cross\u2010Linked Actin Networks (CLANs), dependent on the Rho\/ROCK pathway. Moreover, proteomic analysis of p190A and p190B knockout cells highlighted similar affected cell functions. Finally, our study demonstrates a functional interaction between p190A and p190B where removal of both paralogs is deleterious in endometrial cancer cells, unveiling a potential actionable vulnerability.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.70335","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:26:01Z","timestamp":1789043161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>p190A<\/scp>\n                    \/\n                    <scp>\n                      <i>ARHGAP35<\/i>\n                    <\/scp>\n                    and\n                    <scp>p190B<\/scp>\n                    \/\n                    <scp>\n                      <i>ARHGAP5<\/i>\n                    <\/scp>\n                    proteins in endometrial cancer: a novel cancer\u2010relevant paralog interplay"],"prefix":"10.1002","author":[{"given":"Mathilde","family":"Pinault","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Heraud","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa Correia de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Neaud","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Valesco","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Prouzet\u2010Mauleon","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"},{"name":"CRISP'edit, TBMCore Univ. Bordeaux, CNRS UAR 3427, Inserm US05  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Turcq","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"},{"name":"CRISP'edit, TBMCore Univ. Bordeaux, CNRS UAR 3427, Inserm US05  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010William","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Plateforme Prot\u00e9ome, Univ. Bordeaux  Bordeaux France"},{"name":"OncoProt, TBMCore Univ. Bordeaux, CNRS UAR 3427, Inserm US05  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Aur\u00e9lie","family":"Raymond","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"},{"name":"OncoProt, TBMCore Univ. Bordeaux, CNRS UAR 3427, Inserm US05  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Croce","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"},{"name":"Department of Biopathology Institut Bergoni\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-9680","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Saltel","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"},{"name":"OncoProt, TBMCore Univ. Bordeaux, CNRS UAR 3427, Inserm US05  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lagr\u00e9e","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-7022","authenticated-orcid":false,"given":"Violaine","family":"Moreau","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BRIC, U1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Female genital Tumours, WHO classification of Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_11_3_1","first-page":"34","article-title":"2 pathogenetic variants of corpus uteri cancer","author":"Bokhman IV","year":"1984","journal-title":"Akush Ginekol (Mosk)"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00549"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature12634","article-title":"Mutational landscape and significance across 12 major cancer types","volume":"502","author":"Kandoth 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