{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:43:52Z","timestamp":1792593832690,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1803723N"],"award-info":[{"award-number":["1803723N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S94923N"],"award-info":[{"award-number":["1S94923N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","award":["KotK_UZA\/2023\/13330"],"award-info":[{"award-number":["KotK_UZA\/2023\/13330"]}],"id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"abstract":"<jats:p>Circulating tumor DNA\u2010based liquid biopsy is increasingly integrated into cancer care, particularly for detecting minimal residual disease, yet patient perspectives remain poorly understood. This single\u2010center, cross\u2010sectional, mixed\u2010methods study assessed recall, knowledge, and attitudes toward liquid biopsy and circulating tumor DNA among 195 patients (median age 65\u2009years; 63% female) undergoing cancer treatment or follow\u2010up, supplemented by focus groups. Although 65% reported prior liquid biopsy, this was confirmed in only 44%, and only 10% had heard of circulating tumor DNA (ctDNA). Correct recall and knowledge on ctDNA were higher among patients with neuroendocrine neoplasms and those with postgraduate education. In hypothetical scenarios assuming proven clinical validity and utility, 62\u201380% supported liquid biopsy\u2010guided clinical action, 74% were comfortable with liquid biopsy replacing tissue biopsy, and 79% accepted its use to guide adjuvant treatment. Most patients anticipated reassurance rather than stress, and 85% expected improved quality of life with home\u2010 or general practitioner\u2010based blood sampling. Overall, patients showed high acceptance of clinically actionable liquid biopsy use, driven by trust and perceived clinical benefit.<\/jats:p>","DOI":"10.1002\/1878-0261.70352","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:23:13Z","timestamp":1792592593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attitudes of cancer patients toward\n                    <scp>ctDNA<\/scp>\n                    \u2010based liquid biopsy for follow\u2010up"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-0371","authenticated-orcid":false,"given":"Siddharth","family":"Chhajlani","sequence":"first","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"},{"name":"Center of Medical Genetics University of Antwerp  Edegem Belgium"},{"name":"Center for Oncological Research University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mari\u00ebn","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics University of Antwerp  Edegem Belgium"},{"name":"Center for Oncological Research University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caro","family":"De Weerdt","sequence":"additional","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure\u2010Anne","family":"Teuwen","sequence":"additional","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"},{"name":"Center for Oncological Research University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Prenen","sequence":"additional","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"},{"name":"Center for Oncological Research University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Janssens","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics University of Antwerp  Edegem Belgium"},{"name":"Department of Medical Genetics Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5305","authenticated-orcid":false,"given":"Timon","family":"Vandamme","sequence":"additional","affiliation":[{"name":"Department of Oncology Antwerp University Hospital  Edegem Belgium"},{"name":"Center for Oncological Research University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41392-024-02021-w","article-title":"Liquid biopsy in cancer current: status, challenges and future prospects","volume":"9","author":"Ma L","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","article-title":"Integrating liquid biopsies into the management of cancer","volume":"14","author":"Siravegna G","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmorw.2024.100076","article-title":"Clinical trial and real\u2010world evidence of circulating tumor DNA monitoring to predict recurrence in patients with resected colorectal cancer","volume":"6","author":"Nguyen HT","year":"2024","journal-title":"ESMO Real World Data Digit Oncol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103109","article-title":"ctDNA as a cancer biomarker: a broad overview","volume":"155","author":"Pessoa LS","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"issue":"12","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/s41591-025-04093-9","article-title":"Liquid biopsies across the cancer care continuum","volume":"31","author":"Landon BV","year":"2025","journal-title":"Nat Med"},{"issue":"9","key":"e_1_2_11_7_1","article-title":"Real\u2010world validity of tissue\u2010agnostic circulating tumor DNA response monitoring in lung cancers treated with chemotherapy, immunotherapy, or targeted agents","volume":"6","author":"Chiang AC","year":"2025","journal-title":"JTO Clin Res 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A state\u2010of\u2010the\u2010art review","author":"Stewart L","year":"2024","journal-title":"J Adv Pract Oncol"},{"issue":"12","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210230","article-title":"Circulating tumor DNA as a minimal residual disease assessment and recurrence risk in patients undergoing curative\u2010intent resection with or without adjuvant chemotherapy in colorectal cancer: a systematic review and meta\u2010analysis","volume":"24","author":"Chidharla A","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/gutjnl-2017-315852","article-title":"Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study","volume":"68","author":"Tie J","year":"2019","journal-title":"Gut"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1878-0261.70352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1878-0261.70352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:23:18Z","timestamp":1792592598000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1878-0261.70352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":35,"alternative-id":["10.1002\/1878-0261.70352"],"URL":"https:\/\/doi.org\/10.1002\/1878-0261.70352","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1878-0261.70352"}}