{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:52:29Z","timestamp":1760316749129,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["RHUS 2016 TROY"],"award-info":[{"award-number":["RHUS 2016 TROY"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Netrin\u20101 and B\u2010cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigate the expression of BCMA and Netrin\u20101 in a large cohort of lymphomas to determine their potential role as biomarkers or therapeutic targets. BCMA and Netrin\u20101 expression was investigated comprehensively using immunohistochemistry in a cohort that included 261 B\u2010cell lymphomas, 45 T\u2010cell lymphomas, and 55 classical Hodgkin lymphomas. Netrin\u20101 displayed a cytoplasmic staining pattern in plasmablastic lymphomas (27\/28, 96%) and classical Hodgkin lymphomas (8\/55, 15%). BCMA displayed cytoplasmic staining in most plasmablastic lymphomas (17\/20, 85%). Among mature B\u2010cell lymphomas, Netrin\u20101 and BCMA displayed sensitive (96% and 85%, respectively) and specific (100% and 95%, respectively) staining in plasmablastic lymphomas. These results suggest that these proteins may help pathologists in complex diagnoses and reinforce the interest in developing clinical trials assessing Netrin\u20101 or BCMA\u2010targeted therapies in plasmablastic lymphoma and classical Hodgkin lymphomas, for which our therapeutic arsenal is weak.<\/jats:p>","DOI":"10.1002\/2056-4538.70027","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T02:07:43Z","timestamp":1744769263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Netrin\u20101 and B\u2010cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-5744","authenticated-orcid":false,"given":"Marie","family":"Donzel","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon 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