{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:37Z","timestamp":1793144017818,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803011"],"award-info":[{"award-number":["81803011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Secretory breast carcinoma (SBC) is a rare tumour defined by\n                    <jats:italic>ETV6\u2010NTRK3<\/jats:italic>\n                    rearrangement, but its clinicopathological spectrum and potential for aggressive behaviour remain incompletely characterised. We retrospectively reviewed 29 SBCs diagnosed between 2014 and 2024, including 28 females and one male aged 12\u201363\u2009years (median 44). Twenty\u2010eight tumours arose in the breast parenchyma and one in axillary accessory breast tissue. Histologically, microcystic and tubular patterns predominated and carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    was common. Most tumours were nuclear grade 1 with rare mitoses (0\u20131\/10 high\u2010power fields, HPF). A single patient with distant metastasis harboured a solid\u2010predominant tumour showing nuclear grade 2\u20133, brisk mitoses (6\/10 HPF), and multifocal necrosis. All tumours demonstrated diffuse S100 and pan\u2010TRK expression. Oestrogen and\/or progesterone receptor staining was observed in 16 of 29 cases (2\u201330% of tumour cells), and all were HER2 negative or low (0\u20131+). Ki\u201067 ranged from 3% to 20% (mean 7%). Fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridisation (FISH) was positive in 17 of 17 tested tumours (14\n                    <jats:italic>ETV6\u2010NTRK3<\/jats:italic>\n                    dual\u2010fusion; 3\n                    <jats:italic>NTRK3<\/jats:italic>\n                    break\u2010apart). In the metastatic case, RNA sequencing confirmed canonical\n                    <jats:italic>ETV6\u2010NTRK3<\/jats:italic>\n                    fusion, while targeted DNA sequencing identified additional variants of uncertain significance (VUS) \u2013\n                    <jats:italic>RANBP2<\/jats:italic>\n                    p.S1843R,\n                    <jats:italic>NUP107<\/jats:italic>\n                    p.K382Q,\n                    <jats:italic>NCOR1<\/jats:italic>\n                    p.A1947V (missense), and\n                    <jats:italic>PREX2<\/jats:italic>\n                    p.G606G (synonymous). All patients underwent surgery, and 14 received adjuvant chemotherapy. During follow\u2010up ranging from 6 to 135\u2009months (median 76), one patient developed lung metastasis and was alive with disease at 88\u2009months; the remaining 28 patients were alive without recurrence or metastasis. In summary, SBC is typically indolent and characterised by\n                    <jats:italic>ETV6\u2010NTRK3<\/jats:italic>\n                    rearrangement with diffuse pan\u2010TRK\/S100 positivity. A solid\u2010predominant pattern with increased cytological atypia, mitotic activity, and necrosis may indicate aggressive potential. Routine\n                    <jats:italic>NTRK<\/jats:italic>\n                    testing supports diagnosis and may help identify patients who could benefit from TRK\u2010inhibitor therapy in advanced disease.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70060","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:17:12Z","timestamp":1762427832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Secretory breast carcinoma: morphologic and molecular heterogeneity with indicators of aggressive potential in a cohort of 29 cases"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-7996","authenticated-orcid":false,"given":"Huayan","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR China"},{"name":"Hillman Cancer Center University of Pittsburgh Medical Center  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"},{"name":"College of Basic Medical Sciences Zhengzhou University  Zhengzhou PR 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