{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T18:19:52Z","timestamp":1769710792801,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed \u2018MCD\u2010like MN\u2019. Patients with histologically confirmed MN showing sparse and segmental subepithelial electron\u2010dense deposits (EDD) but clinically resembling MCD were enrolled, alongside age\u2010 and gender\u2010matched classic MCD and MN controls. Clinicopathological parameters were compared across groups. MN\u2010associated antigens and MCD\u2010related podocyte antigens were analyzed in renal tissues and serum. Among 107 archival MCD cases re\u2010evaluated, 16 were reclassified as MCD\u2010like MN based on EDD presence. Pathologically, these cases demonstrated IgG deposition in podocytes (62.5%), significantly higher than classic MCD (6.2%), but lacked complement activation and showed milder interstitial fibrosis compared to MN. Clinically, MCD\u2010like MN patients presented a shorter disease duration and higher complete remission rates compared to MN (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), resembling classical MCD. Additionally, they had lower serum creatinine levels than MCD patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), which were more similar to MN levels. Furthermore, MN\u2010associated antigens were detected in MCD\u2010like MN cases and some of the serum antibodies' levels were increased, suggesting shared pathogenesis with MN, albeit with distinct immune features. Besides, spectrometry counts of podocyte antigens were not increased, and serum anti\u2010podocyte antibodies were either absent or not elevated compared to MCD patients, ruling out antibody\u2010mediated podocytopathy. Collectively, MCD\u2010like MN represents a distinct MN subtype with atypical MCD\u2010like clinicopathological features, likely driven by a unique immune mechanism divergent from both classic MN and MCD.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70062","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T17:34:42Z","timestamp":1764437682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A membranous nephropathy variant mimicking minimal change disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Chuqi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silin","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengya","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Zhengzhou University  Zhengzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-5474","authenticated-orcid":false,"given":"Xuanli","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-326X","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou PR 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