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Decorin (DCN), a member of the family of small leucine\u2010rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance of DCN in pancreatic cancer, both regarding its dynamics in serum during chemotherapy and its compartmental and cellular distribution in tumour tissue. To this end, repeated on\u2010treatment levels of soluble DCN were measured using proximity extension assay in 124 patients enrolled in a prospective, observational clinical study, inviting patients diagnosed with pancreatic or other pancreatobiliary\u2010type periampullary adenocarcinoma eligible for adjuvant (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930) or first\u2010line palliative (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200994) chemotherapy. Multiplexed immunofluorescence was applied to map DCN and the associated immune landscape in resected tumours. The results showed increasing levels of DCN in serum after initiation of chemotherapy in palliative, but not in adjuvant, patients. A higher rate of change of serum DCN was an independent adverse prognostic factor in both treatment settings. There was no significant association between systemic levels and local DCN expression. Varying expression of DCN was denoted in both tumour cells, immune cells and stroma, but the prognostic significance was mainly assigned to its expression in B cells. In particular, a higher percentage of DCN positive B cells, overall and in interaction with tumour cells, were independent predictors of shorter survival. In summary, this study is the first to demonstrate the potential clinical utility of on\u2010treatment monitoring of systemic DCN in patients with pancreatic cancer. The findings also provide interesting leads for further research into how DCN may interact with the immune microenvironment to promote tumour development and the emergence of chemoresistance.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70066","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T03:17:21Z","timestamp":1765768641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic and local decorin levels mirror the clinical course of pancreatic cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-6187","authenticated-orcid":false,"given":"Maja","family":"Svensson","sequence":"first","affiliation":[{"name":"Division of Oncology and Therapeutic Pathology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Lehn","sequence":"additional","affiliation":[{"name":"Division of Translational Cancer Research, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7995-7154","authenticated-orcid":false,"given":"Hedda","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Division of Oncology and Therapeutic Pathology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-9884","authenticated-orcid":false,"given":"Sofie","family":"Olsson Hau","sequence":"additional","affiliation":[{"name":"Division of Oncology and Therapeutic Pathology, Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Palliative Care and Advanced Home Health Care Primary Health Care Sk\u00e5ne  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-4705","authenticated-orcid":false,"given":"Kristian","family":"Pietras","sequence":"additional","affiliation":[{"name":"Division of Translational Cancer Research, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-5000","authenticated-orcid":false,"given":"Karin","family":"Jirstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Oncology and Therapeutic Pathology, Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Clinical Genetics, Pathology and Molecular Diagnostics Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004147"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11562-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.20.7683"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1283383"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.08.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.2008692"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06807-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr424"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","unstructured":"GoldsboroughT O'CallaghanA InglisF et al.A novel channel invariant architecture for the segmentation of cells and nuclei in multiplexed images using InstanSeg. bioRxiv 2024; 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