{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:04:43Z","timestamp":1785229483596,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA217694"],"award-info":[{"award-number":["P50 CA217694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017050","name":"Cycle for Survival","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019543","name":"Kristen Ann Carr Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recurrent fusions involving\n                    <jats:italic>FGFR1\u20104<\/jats:italic>\n                    genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with\n                    <jats:italic>FGFR<\/jats:italic>\n                    fusions, including their incidence and histotypes, has not been performed. Triggered by an\n                    <jats:italic>FGFR1<\/jats:italic>\n                    \u2010rearranged unclassified high\u2010grade sarcoma with myogenic differentiation, we investigated our molecular database for sarcomas with\n                    <jats:italic>FGFR<\/jats:italic>\n                    gene fusions to assess their recurrent potential and morphologic spectrum. A total of six unclassified sarcomas were identified, occurring in five females and one male, with a median age of 66.5\u2009years. Tumors were located in the uterus and retroperitoneal\/trunk soft tissue. Histologically, all tumors were high grade, composed predominantly of spindle cell morphology with variable cytologic atypia, high mitotic activity, and areas of necrosis. By immunohistochemistry, all tumors demonstrated evidence of myogenic differentiation, with focal or diffuse positivity for one or more markers (desmin, h\u2010caldesmon, smooth muscle actin). However, none of the cases displayed diagnostic features of leiomyosarcoma or other known pathologic entities. Molecular studies revealed recurrent fusions involving\n                    <jats:italic>FGFR1<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093),\n                    <jats:italic>FGFR2<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), and\n                    <jats:italic>FGFR4<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), retaining the kinase domain. Additional recurrent genomic alterations included\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations,\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    homozygous deletions, and\n                    <jats:italic>RB1<\/jats:italic>\n                    alterations. Most patients followed an aggressive clinical course, including metastases and disease\u2010related mortality. These findings expand the spectrum of sarcomas driven by\n                    <jats:italic>FGFR<\/jats:italic>\n                    gene fusions, underscoring the importance of molecular testing for accurate diagnosis and potential targeted therapy in high\u2010grade sarcomas with myogenic features.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70094","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T03:44:08Z","timestamp":1779767048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A subset of high\u2010grade sarcomas with myogenic differentiation are associated with recurrent\n                    <i>FGFR<\/i>\n                    fusions"],"prefix":"10.1002","volume":"12","author":[{"given":"Maximus CF","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-6990","authenticated-orcid":false,"given":"Carla","family":"Saoud","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY 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