{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:04:37Z","timestamp":1785229477087,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1401037"],"award-info":[{"award-number":["25ZR1401037"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303019"],"award-info":[{"award-number":["82303019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oligodendrogliomas exhibit significant morphological overlap with low\u2010grade glioneuronal tumors\/low\u2010grade gliomas with oligodendrocyte\u2010like features, posing challenges in histopathological diagnosis. SOX10, a transcription factor critical for oligodendrocyte maturation and central nervous system myelination, may serve as a diagnostic marker. We evaluated the diagnostic utility of SOX10 immunohistochemical expression in 300 oligodendrogliomas versus 52 low\u2010grade glioneuronal tumors\/low\u2010grade gliomas with oligodendrocyte\u2010like features. Notably, SOX10 was negative in 251\/300 (83.7%) oligodendrogliomas but diffusely positive in 47\/52 (90.4%) low\u2010grade glioneuronal tumors\/low\u2010grade gliomas with oligodendrocyte\u2010like features (except polymorphous low\u2010grade neuroepithelial tumors of the young, PLNTY). SOX10 expression was significantly higher in the latter group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and showed a WHO grade dependent up\u2010regulation in oligodendrogliomas (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The diagnostic utility of SOX10 was evident in IDH1\u2010immunonegative cases, yielding 72% sensitivity, 90.4% specificity, and a 78.3% positive predictive value for oligodendroglioma. Combining H3K27me3 loss with SOX10 negativity markedly improved diagnostic sensitivity for oligodendroglioma to 88.5%, substantially surpassing the 35% sensitivity achieved with H3K27me3 loss alone. Additionally, an immunohistochemical panel comprising SOX10, Olig2, and IDH1 aided in discriminating non\u2010neoplastic oligodendrocyte hyperplasia from oligodendroglioma and evaluating the presence of peritumoral tumor residue, particularly in IDH1\u2010immunonegative oligodendroglioma. In conclusion, SOX10 negativity effectively excludes low\u2010grade glioneuronal tumors\/low\u2010grade gliomas with oligodendrocyte\u2010like features (except PLNTY) and non\u2010neoplastic oligodendrocyte hyperplasia from oligodendrogliomas. SOX10 serves as a specific diagnostic marker, enhancing pathological diagnostic accuracy.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70103","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:20:48Z","timestamp":1782915648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SOX10<\/scp>\n                    distinguishes oligodendrogliomas from low\u2010grade glioneuronal tumors\/low\u2010grade gliomas with oligodendrocyte\u2010like features"],"prefix":"10.1002","volume":"12","author":[{"given":"Danmei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathology Huashan Hospital, Fudan University  Shanghai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology Huashan Hospital, Fudan University  Shanghai PR 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