{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:04:43Z","timestamp":1785229483619,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tropomyosin receptor kinase (TRK) fusions are actionable oncogenic drivers, and pan\u2010TRK immunohistochemistry (IHC) serves as a reliable screening tool for\n                    <jats:italic>NTRK gene<\/jats:italic>\n                    aberrations. However, the expression profile and clinical significance of pan\u2010TRK in meningiomas remain unclear. This study aimed to characterize pan\u2010TRK expression, its correlation with clinicopathological features, and underlying NTRK rearrangement status in meningiomas. We retrospectively analyzed 70 primary intracranial tumor specimens, including 50 meningiomas (21 WHO grade 1, 26 grade 2, and 3 grade 3) and 20 non\u2010meningioma CNS tumors (9 solitary fibrous tumors, 6 hemangioblastomas, and 5 schwannomas) from the First Affiliated Hospital of China Medical University (2020\u20132022). Pan\u2010TRK IHC was performed using the Ventana EPR17341 antibody, with fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) validating\n                    <jats:italic>NTRK gene<\/jats:italic>\n                    aberrations in positive cases. Clinicopathological correlations were analyzed using chi\u2010square\/Fisher's exact tests and Spearman's rank correlation. Pan\u2010TRK immunoreactivity was detected in 12\/50 (24.0%) meningiomas, predominantly with cytoplasmic staining (75.0%). Positivity was significantly higher in high\u2010grade (WHO 2\/3) meningiomas (7\/29, 46.7% versus 3\/21, 14.3% in grade 1;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031) and tumors with Ki\u201067 index \u22655% (7\/15, 46.7% versus 5\/35, 14.3% in Ki\u201067 &lt;5%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). No pan\u2010TRK expression was observed in non\u2010meningioma tumors (0\/20). FISH confirmed\n                    <jats:italic>NTRK gene<\/jats:italic>\n                    aberrations in 2\/12 (16.7%) pan\u2010TRK\u2010positive cases (both WHO 3 anaplastic meningiomas), with strong\/moderate IHC staining correlating with aberrations. Pan\u2010TRK is frequently expressed in meningiomas, particularly in high\u2010grade and proliferative tumors, and may have preliminary utility in differentiating meningiomas from other CNS tumors. However,\n                    <jats:italic>NTRK gene<\/jats:italic>\n                    aberrations are rare, necessitating FISH or next\u2010generation sequencing confirmation for pan\u2010TRK\u2010positive cases to identify candidates for TRK\u2010targeted therapy. Further studies are needed to clarify the biological role of non\u2010fusion\u2010mediated pan\u2010TRK overexpression in meningioma progression.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70105","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:16:57Z","timestamp":1782915417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pan\u2010\n                    <scp>TRK<\/scp>\n                    expression and\n                    <scp>\n                      <i>NTRK<\/i>\n                    <\/scp>\n                    gene aberrations in meningiomas: association with tumor grade and proliferative activity"],"prefix":"10.1002","volume":"12","author":[{"given":"Yinan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"},{"name":"Department of Pathology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0986-6032","authenticated-orcid":false,"given":"Xuyong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Hospital of China Medical University  Shenyang PR China"},{"name":"Department of Pathology College of Basic Medical Sciences of China Medical University  Shenyang PR 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