{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:50:20Z","timestamp":1791535820724,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nodular fasciitis (NF) is a benign myofibroblastic neoplasm characterized by rapid growth and recurrent\n                    <jats:italic>USP6<\/jats:italic>\n                    rearrangements. Despite its benign nature, NF may exhibit worrisome histologic or clinical features that mimic sarcoma, posing diagnostic challenges. The relationship between molecular diversity and morphologic heterogeneity remains incompletely understood. We retrospectively analyzed 283 NF cases diagnosed between 2000 and 2024 at a tertiary referral center. Molecular testing for\n                    <jats:italic>USP6<\/jats:italic>\n                    rearrangements was performed in 44 cases using targeted RNA sequencing. Histologic features, clinical parameters, and fusion partner distribution were evaluated, with emphasis on lesions showing infiltrative or worrisome morphology. Selected cases underwent additional genomic profiling, including hybrid\u2010capture DNA sequencing and copy\u2010number analysis. Among 44 molecularly confirmed cases, 18 distinct\n                    <jats:italic>USP6<\/jats:italic>\n                    fusion partners were identified. The most frequent fusion was\n                    <jats:italic>MYH9<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    (40.9%), followed by\n                    <jats:italic>COL1A1<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    ,\n                    <jats:italic>MIR22HG<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    , and\n                    <jats:italic>RRBP1<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    . Rare and previously unreported fusions, including\n                    <jats:italic>CLK1<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    and\n                    <jats:italic>FOSL2<\/jats:italic>\n                    ::\n                    <jats:italic>USP6<\/jats:italic>\n                    , further expanded the molecular spectrum. Two cases with infiltrative, aggressive\u2010appearing morphology showed no additional pathogenic alterations and a genomically stable profile. Based on these findings, we propose an exploratory, hypothesis\u2010generating framework to summarize the observed clinicopathological spectrum of NF. NF demonstrates substantial molecular heterogeneity but retains a genetically simple and largely benign biological behavior. Even lesions with alarming morphology appear genomically stable and clinically indolent. The proposed framework may facilitate diagnostic interpretation and provide a conceptual framework for future studies but requires validation before any biological or clinical implications can be inferred.\n                  <\/jats:p>","DOI":"10.1002\/2056-4538.70117","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:14:28Z","timestamp":1791533668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The molecular landscape of nodular fasciitis: novel\n                    <scp>USP6<\/scp>\n                    fusions, genomic stability, and an exploratory clinicopathological model \u2013 a 20\u2010year retrospective study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-8164","authenticated-orcid":false,"given":"Kristijan","family":"Skok","sequence":"first","affiliation":[{"name":"Diagnostic and Research Institute of Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian T","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-0899","authenticated-orcid":false,"given":"Maria Anna","family":"Smolle","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2295-2622","authenticated-orcid":false,"given":"Theresa","family":"Godschachner","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2598-2325","authenticated-orcid":false,"given":"Andreas","family":"Leithner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Viertler","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2229-5535","authenticated-orcid":false,"given":"Bernadette","family":"Liegl\u2010Atzwanger","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Soft Tissue and Bone Tumours","author":"WHO Classification of Tumors Editorial 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