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In this study, we explored the role of \u03b2\u2010catenin in this process. C57BL\/6 mice received daily intraperitoneal injection with 10% of the body weight of saline (control), 4.25% glucose peritoneal dialysis fluid (PDF), or PDF combined with 5 mg\u00b7kg<jats:sup>\u22121<\/jats:sup> of the \u03b2\u2010catenin inhibitor ICG\u2010001 (PDF+ICG) for 30 days. Also, mice peritoneal epithelial cells (mPECs) were cultured in 4.25% glucose (HG) or combined with 10 \u03bc<jats:sc>m<\/jats:sc> ICG\u2010001 (HG+ICG) for 48 h. We found greater thickness of the parietal peritoneum in the PDF\u2010treated mice. Additionally, lower expression of E\u2010cadherin, higher expression of Vimentin, \u03b2\u2010catenin, and Snail, and activation of \u03b2\u2010catenin was observed in the mice and in HG\u2010treated mPECs, all of which were reversed by ICG\u2010001. The changes in E\u2010cadherin and Vimentin indicated occurrence of the epithelial\u2010to\u2010mesenchymal transition (EMT). Thus, \u03b2\u2010catenin signaling participates in the process of HG\u2010induced peritoneal fibrosis, and the EMT of peritoneal epithelial cells is one of the underlying mechanisms of this pathological change.<\/jats:p>","DOI":"10.1002\/2211-5463.12182","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T08:22:38Z","timestamp":1482049358000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Beta\u2010catenin participates in dialysate\u2010induced peritoneal fibrosis <i>via<\/i> enhanced peritoneal cell epithelial\u2010to\u2010mesenchymal transition"],"prefix":"10.1002","volume":"7","author":[{"given":"Shuiyu","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Nephrology The People's Hospital of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First People's Hospital of Tongxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rending","family":"Wang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Pang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology The People's Hospital of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology The People's Hospital of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Shen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00180.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0963-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006111292"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.01.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"SchophuizenCM HoenderopJG MasereeuwRandHeuvelLP(2015)Uremic toxins induce ET\u20101 release by human proximal tubule cells which regulates organic cation uptake time\u2010dependently. 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