{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:26:36Z","timestamp":1759159596848},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20130591"],"award-info":[{"award-number":["BK20130591"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Enterovirus 71 (<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71) is the major causative agent of hand\u2010foot\u2010and\u2010mouth disease in young children and can cause severe cerebral and pulmonary complications and even fatality. This study aimed at elucidating whether and how <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71 infection is regulated by a cellular micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, miR\u2010127\u20105p. We found that miR\u2010127\u20105p can downregulate the expression of <jats:styled-content style=\"fixed-case\">SCARB<\/jats:styled-content>2, a main receptor of <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71, by targeting two potential sites in its 3\u2032 <jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> region and inhibit <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71 infection. Meanwhile, miR\u2010127\u20105p expression was upregulated during <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71 infection. Notably, transfecting cells with miR\u2010127\u20105p mimics led to a significant decrease in viral replication, while inhibition of endogenous miR\u2010127\u20105p facilitated viral replication. Furthermore, our evidence showed that miR\u2010127\u20105p did not affect postentry viral replication. Taken together, these results indicated that miR\u2010127\u20105p inhibited <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>71 replication by targeting the <jats:styled-content style=\"fixed-case\">SCARB<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/2211-5463.12197","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T07:27:12Z","timestamp":1485156432000},"page":"747-758","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["miR\u2010127\u20105p negatively regulates enterovirus 71 replication by directly targeting <scp>SCARB<\/scp>2"],"prefix":"10.1002","volume":"7","author":[{"given":"Chunhong","family":"Feng","sequence":"first","affiliation":[{"name":"Center for Public Health Research Medical School Nanjing University China"},{"name":"School of life sciences Nanjing University 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