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Several micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> contribute to <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> initiation and progression, but the mechanisms are not clear. Here, we found that miR\u201030d is downregulated in the pleural <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cell line <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H2452, in the plasma of asbestos\u2010exposed individuals, and in asbestos\u2010exposed mesothelial cells. Furthermore, we investigated the influence of the overexpression of miR\u201030d in pleural <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cells. We demonstrated that miR\u201030d overexpression could suppress pleural <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cell proliferation, migration, and invasion <jats:italic>in vitro<\/jats:italic> and could promote cell apoptosis but could not significantly influence cell cycle. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expression of vimentin and <jats:styled-content style=\"fixed-case\">TWIST<\/jats:styled-content>1 decreased, and the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>1 increased in <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H2452 cells that overexpressed miR\u201030d. We therefore conclude that miR\u201030d is related to asbestos exposure and inhibits cell migration and invasion by regulating the epithelial\u2013mesenchymal transition in <jats:styled-content style=\"fixed-case\">NCI<\/jats:styled-content>\u2010H2452 cells.<\/jats:p>","DOI":"10.1002\/2211-5463.12274","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T19:39:01Z","timestamp":1501789141000},"page":"1469-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["miR\u201030d is related to asbestos exposure and inhibits migration and invasion in <scp>NCI<\/scp>\u2010H2452 cells"],"prefix":"10.1002","volume":"7","author":[{"given":"Li","family":"Ju","sequence":"first","affiliation":[{"name":"Institute of Occupational Diseases Zhejiang Academy of Medical Sciences (ZJAMS) Hangzhou Zhejiang 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