{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T19:54:01Z","timestamp":1726430041850},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600469","81472685","81602550"],"award-info":[{"award-number":["81600469","81472685","81602550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2012HM066"],"award-info":[{"award-number":["ZR2012HM066"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Muscle RING\u2010finger (MuRF) proteins are E3 ubiquitin ligases that are expressed in striated muscle. MuRF2 is an important member of this family, but whether it is expressed in tissues other than striated muscle has not been thoroughly elucidated to date. In this study, we determined that Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 is also expressed in other vital organs, including liver, lung, brain, spleen and kidney. Moreover, we show that the level of Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 expression is significantly decreased in hepatic mononuclear cells of mice with lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>)\/<jats:sc>d<\/jats:sc>\u2010galactosamine\u2010induced hepatitis and negatively correlated with the serum levels of alanine aminotransferase and aspartate aminotransferase in these mice. Furthermore, the expression of Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 was down\u2010regulated in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells activated with <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> but not in cells treated with polyinosinic\u2010polycytidylic acid (Poly(I:C)) or with lipidosome plus Poly(I:C). We also found that Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 was able to translocate from the cytoplasm to the nucleus in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells activated with <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> but not in cells treated with Poly(I:C). In addition, we demonstrated that interleukin 6 and tumour necrosis factor \u03b1 production and macrophage migration were inhibited after MuRF2 was overexpressed in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 cells. We further verified that nuclear factor\u2010\u03baB p65 subunit level was greatly reduced in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 macrophage nuclei by gain of function. Taken together, these findings indicate that Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 may rescue <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced macrophage activation by suppressing the production of proinflammatory cytokines and cell migration. We also identify a novel function of Mu<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>2 in non\u2010muscle tissues and cells.<\/jats:p>","DOI":"10.1002\/2211-5463.12367","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T14:02:47Z","timestamp":1513260167000},"page":"234-243","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The E3 ubiquitin ligase MuRF2 attenuates LPS\u2010induced macrophage activation by inhibiting production of inflammatory cytokines and migration"],"prefix":"10.1002","volume":"8","author":[{"given":"Hongjun","family":"Bian","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong University Jinan China"},{"name":"Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control Jinan 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