{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:01:42Z","timestamp":1790845302291,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:00:00Z","timestamp":1522454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/10000964710.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["CUP C75E17000050001"],"award-info":[{"award-number":["CUP C75E17000050001"]}],"id":[{"id":"10.13039\/10000964710.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The protein MucR from <jats:italic>Brucella<\/jats:italic> spp. is involved in the expression regulation of genes necessary for host interaction and infection. MucR is a member of the Ros\/MucR family, which comprises prokaryotic zinc\u2010finger proteins and includes Ros from <jats:italic>Agrobacterium tumefaciens<\/jats:italic> and the Ml proteins from <jats:italic>Mesorhizobium loti<\/jats:italic>. MucR from <jats:italic>Brucella<\/jats:italic> spp. can regulate the expression of virulence genes and repress its own gene expression. Despite the well\u2010known role played by MucR in the repression of its own gene, no target sequence has yet been identified in the <jats:italic>mucR<\/jats:italic> promoter gene. In this study, we provide the first evidence that MucR from <jats:italic>Brucella abortus<\/jats:italic> binds more than one target site in the promoter region of its own gene, suggesting a molecular mechanism by which this protein represses its own expression. Furthermore, a circular dichroism analysis reveals that MucR is a heat\u2010stable protein. Overall, the results of this study suggest that MucR might resemble a H\u2010<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> protein.<\/jats:p>","DOI":"10.1002\/2211-5463.12411","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T07:32:37Z","timestamp":1519975957000},"page":"711-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MucR binds multiple target sites in the promoter of its own gene and is a heat\u2010stable protein: Is MucR a H\u2010<scp>NS<\/scp>\u2010like protein?"],"prefix":"10.1002","volume":"8","author":[{"given":"Ilaria","family":"Baglivo","sequence":"first","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies University of Campania \u2018Luigi Vanvitelli\u2019 Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Pirone","sequence":"additional","affiliation":[{"name":"Institute of Biostructures and Bioimaging C.N.R. 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