{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:49:56Z","timestamp":1778665796832,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:00:00Z","timestamp":1549065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313420"],"award-info":[{"award-number":["2016A030313420"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Dengue fever (<jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>) and dengue hemorrhagic fever (<jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content>) are recurrent diseases that are widespread in the tropics. Here, we identified candidate genes associated with these diseases by performing integrated analyses of <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content> (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE51808\">GSE51808<\/jats:ext-link>) and <jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content> (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE18090\">GSE18090<\/jats:ext-link>) microarray datasets in the Gene Expression Omnibus (<jats:styled-content style=\"fixed-case\">GEO<\/jats:styled-content>). In all, we identified 7635 differentially expressed genes (<jats:styled-content style=\"fixed-case\">DEG<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content> and 8147 <jats:styled-content style=\"fixed-case\">DEG<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content> as compared to healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, we discovered 215 differentially expressed long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content> and 225 <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content>. There were 1256 common <jats:styled-content style=\"fixed-case\">DEG<\/jats:styled-content>s and eight common <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">DHF <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DHF <\/jats:styled-content><jats:italic>vs<\/jats:italic> normal control, and <jats:styled-content style=\"fixed-case\">DF <\/jats:styled-content><jats:italic>vs<\/jats:italic> normal control groups. Gene Ontology (<jats:styled-content style=\"fixed-case\">GO<\/jats:styled-content>) and Kyoto Encyclopedia of Genes and Genomes (<jats:styled-content style=\"fixed-case\">KEGG<\/jats:styled-content>) enrichment analysis revealed that signal transduction (false discovery rate\u00a0=\u00a08.33E\u201010), \u2018toxoplasmosis\u2019, and \u2018protein processing in endoplasmic reticulum\u2019 were significantly enriched pathways for common <jats:styled-content style=\"fixed-case\">DEG<\/jats:styled-content>s. We conclude that the <jats:italic>MAGED1<\/jats:italic>,<jats:italic>STAT1<\/jats:italic>, and <jats:italic>IL12A<\/jats:italic> genes may play crucial roles in <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content>, and suggest that our findings may facilitate the identification of biomarkers and the development of new drug design strategies for <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DHF<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1002\/2211-5463.12576","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T11:08:54Z","timestamp":1545217734000},"page":"468-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genome\u2010wide profiling of <scp>mRNA<\/scp> and lnc<scp>RNA<\/scp> expression in dengue fever and dengue hemorrhagic fever"],"prefix":"10.1002","volume":"9","author":[{"given":"Xiao\u2010Lan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Quality Control Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Ming","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medicine Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Sheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medicine Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Jun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medicine Huadu Hospital of Southern Medical University &amp; Guangzhou Huadu District People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Ping","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0755"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1144"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-016-3855-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-03-0208"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/318479"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.020456"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000215"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-405"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-335"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008261"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.7.2793"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.174052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2014.0204"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.5.2345"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048240"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20026"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-0276108062013012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5870"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)30011-X"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.459"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004548"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45171"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90230-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0820"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038202"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01766-17"}],"container-title":["FEBS 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