{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:58:24Z","timestamp":1767135504287,"version":"build-2238731810"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    Polycystic ovary syndrome (\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    ) is a major cause of anovulatory sterility in women, and most\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    patients exhibit hyperandrogenism (\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    ). Liver kinase b1 (\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1) is a tumor suppressor that has recently been reported to be involved in\n                    <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>\n                    . However, the mechanism by which\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 affects\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    has not previously been elucidated. We report here that ovarian\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 levels are significantly decreased in a female mouse model of\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    . Moreover, we report that\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 expression is inhibited by elevated androgens via activation of androgen receptors. In addition,\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 treatment was observed to suppress androgen synthesis in theca cells and promote estrogen production in granulosa cells by regulating steroidogenic enzyme expression. As expected,\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 knockdown inhibited estrogen levels and enhanced androgen levels, and\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1\u2010transgenic mice were protected against\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    . The effect of\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 appears to be mediated via\n                    <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\n                    \u20101 signaling. In summary, we describe here a key role for\n                    <jats:styled-content style=\"fixed-case\">LKB<\/jats:styled-content>\n                    1 in controlling sex hormone levels.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.12723","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T08:55:12Z","timestamp":1566377712000},"page":"1817-1825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["RETRACTED:\n                    <scp>LKB<\/scp>\n                    1 suppresses androgen synthesis in a mouse model of hyperandrogenism via\n                    <scp>IGF<\/scp>\n                    \u20101 signaling"],"prefix":"10.1002","volume":"9","author":[{"given":"Ying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology the 476th Hospital of PLA Fuzhou China"},{"name":"Fuzong Clinical College Fujian Medical University 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