{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:31:37Z","timestamp":1780608697678,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Obesity during pregnancy has been shown to increase the risk of metabolic diseases in the offspring. However, the factors within the maternal milieu which affect offspring phenotypes and the underlying mechanisms remain unknown. The adipocyte hormone leptin plays a key role in regulating energy homeostasis and is known to participate in sex\u2010specific developmental programming. To examine the action of leptin on fetal growth, placental gene expression and postnatal offspring metabolism, we injected C57BL mice with leptin or saline on gestational day 12 and then measured body weights (BWs) of offspring fed on a standard or obesogenic diet, as well as mRNA expression levels of insulin\u2010like growth factors and glucose and amino acid transporters. Male and female offspring born to leptin\u2010treated mothers exhibited growth retardation before and a growth surge after weaning. Mature male offspring, but not female offspring, exhibited increased BWs on a standard diet. Leptin administration prevented the development of hyperglycaemia in the obese offspring of both sexes. The placentas of the male and female foetuses differed in size and gene expression, and leptin injection decreased the fetal weights of both sexes, the placental weights of the male foetuses and placental gene expression of the GLUT1 glucose transporter in female foetuses. The data suggest that mid\u2010pregnancy is an ontogenetic window for the sex\u2010specific programming effects of leptin, and these effects may be exerted via fetal sex\u2010specific placental responses to leptin administration.<\/jats:p>","DOI":"10.1002\/2211-5463.12757","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T17:35:24Z","timestamp":1573234524000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sex\u2010specific effects of leptin administration to pregnant mice on the placentae and the metabolic phenotypes of offspring"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-8781","authenticated-orcid":false,"given":"Elena I.","family":"Denisova","sequence":"first","affiliation":[{"name":"Laboratory of Physiological Genetics Institute of Cytology and Genetics the Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria V.","family":"Kozhevnikova","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Genetics Institute of Cytology and Genetics the Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda M.","family":"Bazhan","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Genetics Institute of Cytology and Genetics the Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia"},{"name":"Department of Physiology Novosibirsk State University Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Makarova","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Genetics Institute of Cytology and Genetics the Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1237424"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0628"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04293.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295-1311"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00162.2013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1760013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1247"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1039"},{"key":"e_1_2_9_10_1","first-page":"370","article-title":"The influence of hyperleptinemia during pregnancy on fetal weight and obesity development in progeny mice with agouti yellow mutation","volume":"100","author":"Makarova EN","year":"2014","journal-title":"Ross Fiziol Zh Im I M Sechenova"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00676.2006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1119"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00312.2014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.181214"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0006-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.230"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1407-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014398"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.117259"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.156133"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348677"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.22.4692"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.04.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1328"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2007.00150.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02334-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.550004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1153"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-116889"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21165"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021332"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.01.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.7.8227"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.02046.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.18699\/VJ18.376"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.012641"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0188-3"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.110320"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00028"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.9.5369"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0512"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271057"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.103218"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F2211-5463.12757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.12757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.12757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.12757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T09:38:05Z","timestamp":1733737085000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.12757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/2211-5463.12757"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.12757","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737172017.793569787","asserted-by":"object"}]},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"2019-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}