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The comprehensive DNA methylation status of GC cells obtained from an advanced EBV\u2010associated GC (EBVGC) case, in which complete response to S\u20101 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, <jats:italic>ABCG2, AHNAK2, BCL2, FZD1,<\/jats:italic> and <jats:italic>TP73<\/jats:italic> are associated with published evidence for resistance to 5\u2010fluorouracil and cisplatin. 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