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Vascular endothelium growth factor A (VEGFA) has been found to be upregulated in the articular cartilage, synovium and subchondral bone of OA patients, leading to cartilage degeneration, synovitis and osteophyte formation. However, the functions and mechanisms of LIPUS in regulating chondrocyte\u2010derived VEGFA expression are still unclear. In this study, we investigated whether LIPUS attenuated OA progression by (a) decreasing the percentage of VEGFA\u2010positive cells in mouse articular cartilage destabilised through medial meniscus surgery and (b) relieving interleukin\u20101\u03b2\u2010induced VEGFA expression in mouse primary chondrocytes. However, this function was negated by a p38 mitogen\u2010activated protein kinase (p38 MAPK) inhibitor. In addition, we found that LIPUS ameliorated VEGFA\u2010mediated disorders in cartilage extracellular matrix metabolism and chondrocyte hypertrophy during OA development. In conclusion, our data indicate a novel effect of LIPUS in regulating the expression of osteoarthritic chondrocyte\u2010derived VEGFA through the suppression of p38 MAPK activity.<\/jats:p>","DOI":"10.1002\/2211-5463.12801","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T03:00:20Z","timestamp":1579834820000},"page":"434-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Low\u2010intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis"],"prefix":"10.1002","volume":"10","author":[{"given":"Mengtong","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine The First Affiliated Hospital of Chongqing Medical University 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