{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:58:27Z","timestamp":1785160707026,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    Both antibiotic\u2010impregnated poly(methyl acrylate, methyl methacrylate) (PMMA) and antibiotic\u2010impregnated calcium sulfate have been successfully used as local antibiotic delivery vehicles for the management of chronic osteomyelitis. Here, we examined the antibiotic elution characteristics and antibacterial properties of a composite drug delivery system consisting of PMMA\/calcium sulfate carrying vancomycin (dual carrier\u2010v) against\n                    <jats:italic>Staphylococcus\u00a0aureus<\/jats:italic>\n                    , with PMMA loaded with vancomycin (PMMA\u2010v) as a control. Vancomycin gradually degraded from dual carrier\u2010v and PMMA\u2010v up to about 8 and 6\u00a0weeks, respectively. At different elution time points, the inhibition zones of the dual carrier\u2010v were larger than the inhibition zones of the PMMA\u2010v (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). The colony inhibition rate of the dual carrier\u2010v was 95.57%, whereas it was 77.87% for PMMA\u2010v. Scanning electron microscopy was used to demonstrate biofilm formation on the surface of plates treated with vancomycin\u2010unloaded PMMA, whereas there was no biofilm formation on the surface of plates treated with dual carrier\u2010v or PMMA\u2010v. The dual carrier\u2010v was more effective at antibacterial adhesion at each time point after immersion in simulated body fluid as compared with PMMA\u2010v (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). In conclusion, our results suggest that the dual carrier\u2010v can release higher concentrations of antibiotics and inhibit bacteria growth more effectively\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    as compared with PMMA\u2010v. The dual carrier\u2010v thus may have potential as an alternative strategy for osteomyelitis management.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.12809","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T03:20:25Z","timestamp":1581564025000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A dual PMMA\/calcium sulfate carrier of vancomycin is more effective than PMMA\u2010vancomycin at inhibiting\n                    <i>Staphylococcus\u00a0aureus<\/i>\n                    growth\n                    <i>in\u00a0vitro<\/i>"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-0035","authenticated-orcid":false,"given":"Shanchao","family":"Luo","sequence":"first","affiliation":[{"name":"Yulin Orthopedics Hospital of Chinese and Western Medicine Yulin China"},{"name":"Guangxi Postdoctoral Innovation Practice Base 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