{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:56:33Z","timestamp":1770069393821,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1)\u2010induced protein\u20108 like\u20102 (TIPE2) is a newly identified protein that negatively regulates the activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in AH in children. We observed that the levels of TNF\u2010\u03b1 and interleukin\u20106 were greater in the adenoid tissue of AH children than in healthy control subjects (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and this increase was positively correlated with the severity of AH. The level of TIPE2 expression was decreased compared with control and was negatively correlated with AH. TIPE2 overexpression in primary human monocytes (isolated from adenoid tissue of children with AH) inhibited the activation of nuclear factor\u2010\u03baB and the expression of TNF\u2010\u03b1 and interleukin\u20106. These results suggest that overexpression of TIPE2 may attenuate AH through inactivation of the nuclear factor\u2010\u03baB signaling pathway.<\/jats:p>","DOI":"10.1002\/2211-5463.12821","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T05:51:26Z","timestamp":1582696286000},"page":"761-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Down\u2010regulation of anti\u2010inflammatory TIPE2 may aggravate adenoidal hypertrophy in children"],"prefix":"10.1002","volume":"10","author":[{"given":"Kun","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Qilu Hospital of Shandong University NHC Key Laboratory of Otorhinolaryngology (Shandong University) Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-3972","authenticated-orcid":false,"given":"Zhiyong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Shandong Provincial Hospital affiliated to Shandong University Jinan City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2003.10.003"},{"key":"e_1_2_10_3_1","first-page":"443","article-title":"Montelukast in adenoid hypertrophy: its effect on size and symptoms","volume":"27","author":"Shokouhi F","year":"2016","journal-title":"Iran J Otorhinolaryngol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02154.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2011.575426"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.12932\/AP0294.31.2.2013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.09.040"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1522"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.04.017"},{"key":"e_1_2_10_11_1","first-page":"403","article-title":"Declaration of Helsinki. Ethical principles for medical research involving human subjects","volume":"107","author":"World Medical Association Inc.","year":"2009","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2013.67.111-114"},{"key":"e_1_2_10_13_1","first-page":"51","article-title":"Acetylcholine suppresses microglial inflammatory response via \u03b17nAChR to protect hippocampal neurons","volume":"18","author":"Li L","year":"2019","journal-title":"J Integr Neurosci"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36806-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20046"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.06.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276243"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.018"},{"key":"e_1_2_10_19_1","first-page":"S1","article-title":"Adenoid hypertrophy: definition of some risk factors","volume":"26","author":"De Amici M","year":"2012","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00797.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1228704"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2F2211-5463.12821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.12821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.12821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.12821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:18:46Z","timestamp":1694060326000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.12821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,22]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/2211-5463.12821"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.12821","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,22]]},"assertion":[{"value":"2019-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}