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However, lncRNA expression changes in autoimmune hepatitis (AIH), a form of inflammation induced by immunological tolerance disorders, are poorly understood. Here, for the first time to our knowledge, we used microarrays to profile 1161 differentially expressed lncRNAs (DELs; 608 up\u2010 and 553 down\u2010regulated) and 11\u00a0512 differentially expressed mRNAs (DEMs; 5189 up\u2010 and 6323 down\u2010 regulated) in a concanavalin A\u2010induced AIH mouse model. We used quantitative real\u2010time PCR to confirm the expression of eight DELs and DEMs, and analyzed the coexpression relationship between them. Potential biological functions of screened DELs and DEMs were predicted with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. DEL\u2010DEM interaction networks were also constructed. Our study revealed the roles of DELs and DEMs in the pathogenesis of AIH. We also provided potential candidate biomarkers that may have potential for future development into possible diagnostics or as a treatment for this disorder.<\/jats:p>","DOI":"10.1002\/2211-5463.12953","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T20:21:18Z","timestamp":1598559678000},"page":"2040-2054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Microarray\u2010based transcriptional profiling of a mouse model of autoimmune hepatitis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-5002","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"College of Basic Medical Sciences Shanxi University of Chinese Medicine Jinzhong China"},{"name":"Basic Laboratory of Integrated Traditional Chinese and Western Medicine Shanxi University of Chinese Medicine Jinzhong 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