{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:25:16Z","timestamp":1790227516569,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313889"],"award-info":[{"award-number":["2017A030313889"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules. This can severely affect day\u2010to\u2010day activities and quality of life because of a restricted range of motion in affected joints. The precise pathogenic mechanism underlying joint contractures is not fully understood. Lumican belongs to the class II small leucine\u2010rich repeat proteoglycan superfamily, which makes up collagen fibrils in the extracellular matrix. Lumican is ubiquitously expressed in the skin, liver, heart, uterus and articular cartilage and has reported roles in cell migration, proliferation, angiogenesis and Toll\u2010like receptor 4 signaling. Previous research has suggested that lumican is involved in the pathogenesis of several fibrotic diseases. Because joint contracture resembles a fibrotic disease, we aimed to investigate the role of lumican in the development of joint contracture <jats:italic>in\u00a0vitro<\/jats:italic>. Here, we showed that protein levels were up\u2010regulated in the fibrotic joint capsule versus control. We observed that lumican significantly enhanced the proliferation, migration and fibroblast\u2013myofibroblast transition of synovial fibroblasts. Moreover, lumican led to increased transcription of alpha\u2010smooth muscle actin, matrix metallopeptidase 9, Collagen I, plasminogen activator inhibitor 1 and transforming growth factor\u2010\u03b2 <jats:italic>in\u00a0vitro<\/jats:italic>. Lumican treatment promoted collagen lattice contraction in a dose\u2010dependent manner as early as 24\u00a0h after treatment. Thus, our studies reveal that lumican could promote fibroblast\u2013myofibroblast transition and joint contracture.<\/jats:p>","DOI":"10.1002\/2211-5463.12974","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T14:09:15Z","timestamp":1600956555000},"page":"2478-2488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Lumican promotes joint fibrosis through TGF\u2010\u03b2 signaling"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-6356","authenticated-orcid":false,"given":"Dahai","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Joint and Trauma Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangzhao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Joint and Trauma Surgery The Third 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