{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:32:21Z","timestamp":1778581941074,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Fluorosis is a common disease characterized by disruptions in bone metabolism and enamel development. The production of reactive oxygen species is thought to play an important role in fluorosis. Gastrodin (4\u2010hydroxybenzylalcohol4\u2010O\u2010beta\u2010<jats:sc>D<\/jats:sc>\u2010glucopyranoside) has been reported to have antioxidative activity, and so here we examined whether gastrodin has protective effects against oxidative stress and bone tissue toxicity in rats with fluorosis. Wistar rats were given different doses of gastrodin 1\u00a0month after fluoride administration, and samples of blood, bone and teeth were collected after 2, 3 and 4\u00a0months; glutathione peroxidase glu, CAT and SOD levels in the fluorosis group were lower than those in the control group. Gastrodin treatment in rats ameliorated oxidative stress and fluoride accumulation that were induced by fluoride; treatment with 400\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> gastrodin protected trabecular bone structure and reduced femur and alveolar bone injury in rats with fluorosis. Enhanced expression of cysteinyl aspartate\u2010specific proteinase (caspase) 3, caspase\u20109 and Bax and decreased expression of Bcl\u20102 induced by fluoride were also reversed by gastrodin. In summary, the present data suggest that gastrodin, and in particular a dose of 400\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, can improve the antioxidative capacity of rats, reduce concentration of fluoride in tissues, alleviate bone damage and modulate expression of Bcl\u20102, Bax, caspase\u20103 and caspase\u20109.<\/jats:p>","DOI":"10.1002\/2211-5463.12991","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T14:20:21Z","timestamp":1601734821000},"page":"2404-2416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gastrodin alleviates bone damage by modulating protein expression and tissue redox state"],"prefix":"10.1002","volume":"10","author":[{"given":"Bowen","family":"Zheng","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Liaoning Provincial Key Laboratory of Oral Diseases China Medical University Shenyang 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