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Prefoldin is a heterohexameric molecular complex that binds and delivers unfolded proteins to chaperonin for correct folding. The prefoldin PFD6 is predicted to interact with merozoite surface protein\u20101 (MSP\u20101), a protein well known to play a pivotal role in erythrocyte binding and invasion by <jats:italic>Plasmodium<\/jats:italic> merozoites. We previously found that the <jats:italic>P.\u2009falciparum<\/jats:italic> (<jats:italic>Pf<\/jats:italic>) genome contains six prefoldin genes and a prefoldin\u2010like gene whose molecular functions are unidentified. Here, we analyzed the expression of <jats:italic>Pf<\/jats:italic>PFD\u20106 during the asexual blood stages of the parasite and investigated its interacting partners. <jats:italic>Pf<\/jats:italic>PFD\u20106 was found to be significantly expressed at the trophozoite and schizont stages. Pull\u2010down assays suggest <jats:italic>Pf<\/jats:italic>PFD\u20106 interacts with MSP\u20101. <jats:italic>In\u2009silico<\/jats:italic> analysis suggested critical residues involved in the <jats:italic>Pf<\/jats:italic>PFD\u20106\u2010MSP\u20101 interaction. Our data suggest <jats:italic>Pf<\/jats:italic>PFD\u20106 may play a role in stabilizing or trafficking MSP\u20101.<\/jats:p>","DOI":"10.1002\/2211-5463.13022","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T07:49:33Z","timestamp":1604476173000},"page":"1050-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prefoldin subunit 6 of <i>Plasmodium falciparum<\/i> binds merozoite surface protein\u20101"],"prefix":"10.1002","volume":"12","author":[{"given":"Vikash","family":"Kumar","sequence":"first","affiliation":[{"name":"Special Centre for Molecular Medicine Jawaharlal Nehru University  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumaisha","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Biosciences Faculty of Natural Sciences Jamia Millia Islamia  New Delhi 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