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We previously showed that the transcription regulator Bach2 regulated abnormal B\u2010cell activation in SLE. Here, we investigated whether Bach2 was also involved in Th9 cell differentiation in SLE. We found that the proportion of Th9 cells was enhanced in the peripheral blood mononuclear cells (PBMC) of SLE patients. The PBMC and CD4<jats:sup>+<\/jats:sup> T cells of SLE patients exhibited a decrease of Bach2 expression and an increase of IL\u20109 expression. Furthermore, Bach2 overexpression significantly repressed the levels of PU.1, IRF4, IL\u20109, and Th9 cells in the CD4<jats:sup>+<\/jats:sup> T cells of SLE patients and healthy volunteers. In addition, Bach2 overexpression inhibited the levels of IL\u20109 and Th9 cells, whereas IRF4 upregulation enhanced the levels of IRF4 and IL\u20109 and Th9 cells in the CD4<jats:sup>+<\/jats:sup> T cells of SLE patients and healthy volunteers. The effect of IRF4 up\u2010regulation was abolished by Bach2 overexpression. 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