{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:47:58Z","timestamp":1766515678049,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Herein, we investigated the activity of XOR in a mouse model of aristolochic acid I (AA)\u2010induced nephropathy, a type of nephrotoxic chronic kidney disease (CKD). A persistent decrease in renal function was observed in mice up to 4\u00a0weeks after 4\u00a0weeks of AA (2.5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) administration. Renal histology revealed an increase in tubular interstitial fibrosis over time. Although AA administration did not change XOR activity in the plasma, heart, liver, or muscle, XOR activity was persistently increased in renal tissue. Our results suggest that the renal tissue\u2010specific increase in XOR activity is involved in the progression of tubulo\u2010interstitial disorders, specifically fibrosis.<\/jats:p>","DOI":"10.1002\/2211-5463.13083","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:28:54Z","timestamp":1610753334000},"page":"507-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-260X","authenticated-orcid":false,"given":"Takeo","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"},{"name":"Department of Medicine Yokohama Daiichi Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Kumagae","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"},{"name":"Department of General Internal Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Wakui","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Urate","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Kinguchi","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Haruhara","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2324-3569","authenticated-orcid":false,"given":"Takashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Sanwa Kagaku Kenkusho., Co., Ltd Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"},{"name":"Department of General Internal Medicine Shonan Kamakura General Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.07.010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.09.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1819-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-017-2014-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70343-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm167"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.092839"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13584"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10370"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00346-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.086"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00650"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583500004479"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1032702"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124480"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120305"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198802000-00001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.11.7649415"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13089"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8603164"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13970-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346180"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00572"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001594"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.95"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000130"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.11.030"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95978"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.264"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13486-x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094778"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7555"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.09.010"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0318-124R"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01366-3"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(98)00028-2"},{"key":"e_1_2_11_38_1","first-page":"G281","article-title":"A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF\u2010kappaB","volume":"272","author":"Mirza A","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080025"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084235"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10102146"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050563"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.135152"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.01.005"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.13083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T15:38:42Z","timestamp":1730475522000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/2211-5463.13083"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13083","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"type":"print","value":"2211-5463"},{"type":"electronic","value":"2211-5463"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}