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Recently, the importance of epigenetic regulation of placental genes has been emphasized in the study of developmental defects and placental disease. In this study, the role of the CCCTC\u2010binding factor (CTCF) in regulation of PSG expression was investigated to better understand the epigenetic regulatory mechanisms of the PSG genes. Inhibition of CTCF expression disturbed transcription of several PSG genes: <jats:italic>PSG1<\/jats:italic>, <jats:italic>PSG2<\/jats:italic>, <jats:italic>PSG4<\/jats:italic>, <jats:italic>PSG5<\/jats:italic>, <jats:italic>PSG8<\/jats:italic>, and <jats:italic>PSG9<\/jats:italic> were upregulated and <jats:italic>PSG6<\/jats:italic> and <jats:italic>PSG11<\/jats:italic> were downregulated. These transcriptional changes were correlated with decreased CTCF binding and changes in histone modification at the PSG promoters. Our data demonstrate that CTCF is a potential mediator in the regulation of PSG gene expression.<\/jats:p>","DOI":"10.1002\/2211-5463.13087","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T09:28:09Z","timestamp":1610789289000},"page":"804-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Depletion of CTCF disrupts PSG gene expression in the human trophoblast cell line Swan 71"],"prefix":"10.1002","volume":"11","author":[{"given":"Da Som","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Anatomy Embryology Laboratory Yonsei University College of Medicine Seoul Korea"},{"name":"Brain Korea 21 PLUS project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Embryology 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