{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:21:23Z","timestamp":1791901283912,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Hypertrophic scarring (HS) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. The aim of this study is to explore crucial long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with HS and provide a better understanding of the molecular mechanism of HS. To investigate the lncRNA, circRNA and mRNA expression profiles, we performed RNA sequencing of human HS and normal skin tissues. After the identification of differentially expressed mRNAs (DEmRNAs), lncRNAs (DElncRNAs) and circRNAs (DEcircRNAs), we performed functional enrichment of DEmRNAs. Further on, we constructed DElncRNA\/DEcircRNA\u2013DEmRNA coexpression networks and competing endogenous RNA regulatory networks, and performed functional analyses of the DEmRNAs in the constructed networks. In total, 487 DEmRNAs, 92 DElncRNAs and 17 DEcircRNAs were identified. DEmRNAs were significantly enriched in processes such as collagen fibril organization, extracellular matrix\u2013receptor interaction and the phosphatidylinositol 3\u2010kinase (PI3K)\u2013Akt signaling pathway. In addition, we detected 580 DElncRNA\u2013DEmRNA and 505 DEcircRNA\u2013DEmRNA coexpression pairs. The competing endogenous RNA network contained 18 circRNA\u2013microRNA (miRNA) pairs, 18 lncRNA\u2013miRNA pairs and 409 miRNA\u2013mRNA pairs, including 10 circRNAs, 5 lncRNAs, 15 miRNAs and 160 mRNAs. We concluded that MIR503HG\/hsa\u2010miR\u2010204\u20103p\/\n                    <jats:italic>ACAN<\/jats:italic>\n                    , MIR503HG\/hsa\u2010miR\u2010431\u20105p\/\n                    <jats:italic>TNFRSF9<\/jats:italic>\n                    , MEG3\/hsa\u2010miR\u20106884\u20105p\/\n                    <jats:italic>ADAMTS14<\/jats:italic>\n                    , AC000035.1\u2010\n                    <jats:italic>ADAMTS14<\/jats:italic>\n                    and hsa_circ_0069865\u2010\n                    <jats:italic>COMP<\/jats:italic>\n                    \/\n                    <jats:italic>ADAM12<\/jats:italic>\n                    interaction pairs may play a central role in HS.\n                  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