{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:16:39Z","timestamp":1786976199209,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670881"],"award-info":[{"award-number":["81670881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["2014pt\u2010sy10002"],"award-info":[{"award-number":["2014pt\u2010sy10002"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Choroidal neovascularization (CNV) is a key characteristic of wet age\u2010related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti\u2010VEGF therapy is currently the premier strategy for wet AMD, but it has limited efficacy. Previous studies have shown that chitinase\u20103\u2010like\u20101 (YKL\u201040) can promote microangiogenesis and inflammation, but its effect on CNV formation has not yet been studied. Here, we investigated the potential role of YKL\u201040 in wet AMD and the underlying mechanism(s). We report that the serum expression of YKL\u201040 in wet AMD patients was significantly higher than that in control patients and was positively correlated with VEGF expression, indicating that YKL\u201040 may participate in the development of wet AMD. In addition, YKL\u201040 and VEGF expression levels were observed to be increased and the ERK1\/2 pathway activated in the neuroretinal (NR) and RPE\/choroid tissues of mice with laser\u2010induced CNV. The YKL\u201040 and phosphorylated protein levels of the ERK1\/2 pathway were decreased after intravitreal injection with an anti\u2010YKL\u201040 antibody, suggesting that anti\u2010YKL\u201040 could inhibit the activation of the ERK1\/2 pathway. These results indicate that YKL\u201040 may serve as a novel target for the diagnosis and treatment of wet AMD.<\/jats:p>","DOI":"10.1002\/2211-5463.13223","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T15:17:58Z","timestamp":1623338278000},"page":"2933-2942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Elevated YKL\u201040 serum levels may contribute to wet age\u2010related macular degeneration via the ERK1\/2 pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Yue","family":"Bin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-3752","authenticated-orcid":false,"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute The First Affiliated Hospital of Chongqing Medical University Chongqing 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