{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:38:27Z","timestamp":1789663107065,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>ATP\u2010sensitive potassium channels (KATPs) have protective effects in ischemia\u2013reperfusion\u2010induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis, and survival in a rat model of acute kidney injury (AKI) following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Rats underwent a 5\u2010min asphyxia\u2010based CA and resuscitation. The rats were treated with levosimendan after successful resuscitation. Renal functions, histological changes, inflammatory responses, and apoptosis were examined. NRK\u201052E cells treated by hypoxia\/reoxygenation (H\/R) were used to establish an <jats:italic>in\u00a0vitro<\/jats:italic> CA\u2010CPR model. Rats in the CA\u2010induced AKI group had a low survival rate and increased levels of creatinine, blood urea nitrogen, and proinflammatory cytokines, as well as increased tubular injury. These results were significantly reversed after treatment with levosimendan. Levosimendan downregulated the expression of the apoptosis\u2010related proteins Bax, cleaved caspase\u20103, and cleaved caspase\u20109, as well as upregulated Bcl\u20102 and p\u2010ERK expression <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro<\/jats:italic>. Thus, our data suggest that levosimendan reduces mortality and AKI following CA and CPR via suppression of inflammation and apoptosis, and activation of ERK signaling.<\/jats:p>","DOI":"10.1002\/2211-5463.13227","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T17:05:40Z","timestamp":1623431140000},"page":"2236-2244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti\u2010inflammation, anti\u2010apoptosis, and ERK activation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-881X","authenticated-orcid":false,"given":"Lei","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Emergency School of Medicine Renji Hospital Shanghai Jiao Tong University 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