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Aberrant epigenetic factor lysine\u2010specific demethylase 6B (KDM6B) has been associated with tumor progression. Here, we show that KDM6B is significantly down\u2010regulated in human breast cancer tissues, and its low expression is associated with poor prognosis of patients with breast cancer. Furthermore, overexpression of KDM6B remarkably inhibited cell proliferation, invasion, migration and epithelial\u2013mesenchymal transition markers of breast cancer cells <jats:italic>in\u00a0vitro<\/jats:italic> and tumor growth and lung metastasis <jats:italic>in\u00a0vivo<\/jats:italic>. Notably, the expression of KDM6B in breast cancer tissues was negatively correlated with that of \u03b2\u2010catenin, and overexpression of KDM6B decreased the expression of \u03b2\u2010catenin and its accumulation in the nucleus of breast cancer cells. Overall, our findings provide novel insights into suppression of metastasis of breast cancer cells by KDM6B via \u03b2\u2010catenin and suggest involvement of the KDM6B\u2010Wnt\/\u03b2\u2010catenin axis in breast cancer progression.<\/jats:p>","DOI":"10.1002\/2211-5463.13236","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T13:00:40Z","timestamp":1624539640000},"page":"2273-2281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt\/\u03b2\u2010catenin signaling"],"prefix":"10.1002","volume":"11","author":[{"given":"Jing","family":"Xun","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair Institute of Acute Abdominal Diseases Tianjin Nankai Hospital 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