{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:29:46Z","timestamp":1788449386096,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["F\/50\/20"],"award-info":[{"award-number":["F\/50\/20"]}],"id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NE 2159\/3\u20101"],"award-info":[{"award-number":["NE 2159\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Adrenergic stimulation, while being the central mechanism of cardiac positive inotropy, is a universally acknowledged inductor of undesirable sarcoplasmic reticulum (SR) Ca\n                    <jats:sup>2+<\/jats:sup>\n                    leak. However, the exact mechanisms for this remained unspecified so far. This study shows that Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/calmodulin\u2010dependent protein kinase II (CaMKII)\u2010specific phosphorylation of ryanodine receptor type 2 at Ser\u20102814 is the pivotal mechanism by which SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    leak develops downstream of \u03b21\u2010adrenergic stress by increase of the leak\/load relationship. Cardiomyocytes with a Ser\u20102814 phosphoresistant mutation (S2814A) were protected from isoproterenol\u2010induced SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    leak and consequently displayed improved postrest potentiation of systolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release under adrenergic stress compared to littermate wild\u2010type cells.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13274","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T11:36:22Z","timestamp":1629200182000},"page":"2756-2762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phosphorylation of RyR2 Ser\u20102814 by CaMKII mediates \u03b21\u2010adrenergic stress induced Ca\n                    <sup>2+<\/sup>\n                    \u2010leak from the sarcoplasmic 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