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In this article, we show that expression of abnormal spindle\u2010like microcephaly\u2010associated protein (ASPM) is up\u2010regulated in liver cancer samples, and this up\u2010regulation is significantly associated with tumor aggressiveness and reduced survival times of patients. Down\u2010regulation of ASPM expression inhibits the proliferation, invasion, migration and epithelial\u2010to\u2010mesenchymal transition of HCC cells <jats:italic>in\u00a0vitro<\/jats:italic> and inhibits tumor formation in nude mice. ASPM interacts with disheveled\u20102 (Dvl2) and antagonizes autophagy\u2010mediated Dvl2 degradation by weakening the functional interaction between Dvl2 and the lipidated form of microtubule\u2010associated proteins 1A\/1B light chain 3A (LC3II), thereby increasing Dvl2 protein abundance and leading to Wnt\/\u03b2\u2010catenin signaling activation in HCC cells. Thus, our results define ASPM as a novel oncoprotein in HCC and indicate that disruption of the Wnt\u2013ASPM\u2013Dvl2\u2013\u03b2\u2010catenin signaling axis might have potential clinical value.<\/jats:p>","DOI":"10.1002\/2211-5463.13278","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T16:16:30Z","timestamp":1629821790000},"page":"2784-2799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["ASPM promotes hepatocellular carcinoma progression by activating Wnt\/\u03b2\u2010catenin signaling through antagonizing autophagy\u2010mediated Dvl2 degradation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-5073","authenticated-orcid":false,"given":"Haifeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology School of Basic Medical Sciences Zhengzhou University 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