{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:26:56Z","timestamp":1790162816468,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773156"],"award-info":[{"award-number":["81773156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970674"],"award-info":[{"award-number":["31970674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>There were approximately 1.93\u2009million new cases and 940\u2009000 deaths from colorectal cancer in 2020. The first\u2010line chemotherapeutic drugs for colorectal cancer are mainly based on 5\u2010fluorouracil, although the use of these drugs is limited by the development of drug resistance. Consequently, there is a need for novel chemotherapeutic drugs for the efficient treatment of colorectal cancer patients. In the present study, we screened 160 drugs approved by the Food and Drug Administration and identified that cabazitaxel (CBT), a microtube inhibitor, can suppress colony formation and cell migration of colorectal cancer cells <jats:italic>in\u2009vitro<\/jats:italic>. CBT also induces G2\/M phase arrest and apoptosis of colorectal cancer cells. Most importantly, it inhibits the growth of colorectal cancer cell xenograft tumors <jats:italic>in\u2009vivo<\/jats:italic>. Transcriptome analysis by RNA\u2010sequencing revealed that Tub family genes are abnormally expressed in CBT\u2010treated colorectal cancer cells. The expression of several p53 downstream genes that are associated with cell cycle arrest, apoptosis, and inhibition of angiogenesis and metastasis is induced by CBT in colorectal cancer cells. Overall, our results suggests that CBT suppresses colorectal cancer by upregulating the p53 pathway, and thus CBT may have potential as an alternative chemotherapeutic drug for colorectal cancer.<\/jats:p>","DOI":"10.1002\/2211-5463.13290","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T20:21:05Z","timestamp":1631132465000},"page":"3032-3050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Institute of Gastroenterology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqian","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Country Garden School Foshan City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Institute of Gastroenterology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Institute of Gastroenterology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Institute of Gastroenterology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medical Sciences,\uff0c Center of Respiratory Medicine China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Pei","sequence":"additional","affiliation":[{"name":"Center for Quantitative Biology,\uff0c Academy for Advanced Interdisciplinary Studies Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-3487","authenticated-orcid":false,"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Institute of Gastroenterology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0061"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5278"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3146"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2615-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0596"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn171"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5648"},{"key":"e_1_2_10_10_1","first-page":"4731","article-title":"The role of transforming growth factor alpha in determining growth factor independence","volume":"63","author":"Awwad RA","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.15.9214"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31471"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103268200"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.37.22044"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-3-r22"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3715"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3437"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10940"},{"key":"e_1_2_10_23_1","first-page":"1297","article-title":"Cabazitaxel, a novel chemotherapeutic alternative for drug\u2010resistant hepatocellular carcinoma","volume":"8","author":"Chen R","year":"2018","journal-title":"Am J Cancer Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30408-5"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000805"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i4.1125"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20896"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591390-000000000-00000"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0909-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14529"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0110-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1801-6"},{"key":"e_1_2_10_34_1","first-page":"8","article-title":"Aberrant methylation of GADD45A is associated with decreased radiosensitivity in cervical cancer through the PI3K\/AKT signaling pathway","volume":"21","author":"Lou M","year":"2021","journal-title":"Oncol Lett"},{"key":"e_1_2_10_35_1","first-page":"1185","article-title":"PIG3 suppresses gastric cancer proliferation by regulating p53\u2010mediated apoptosis","volume":"32","author":"Chu Y","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0244-5"}],"updated-by":[{"DOI":"10.1002\/2211-5463.70256","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000}}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.13290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:28:30Z","timestamp":1747211310000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/2211-5463.13290"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13290","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"2021-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}