{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:41:08Z","timestamp":1785811268728,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017BH089"],"award-info":[{"award-number":["ZR2017BH089"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial\u2010mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of <jats:italic>LC3<\/jats:italic> and <jats:italic>Beclin\u20101<\/jats:italic> in SACC patients and SACC\u201083 cells <jats:italic>in\u2009vitro<\/jats:italic>. Moreover, PRRX1\u2010mediating FFA reprogramming triggered to autophagy via regulating acetyl\u2010CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC.<\/jats:p>","DOI":"10.1002\/2211-5463.13367","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T15:29:13Z","timestamp":1642260553000},"page":"1006-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Paired related homeobox 1 attenuates autophagy via acetyl\u2010CoA carboxylase 1\u2010regulated fatty acid metabolism in salivary adenoid cystic carcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Jie","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Oral Implantology The Affiliated Hospital of Qingdao University  China"},{"name":"School of Stomatology of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangjie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology The Affiliated Hospital of Qingdao University  China"},{"name":"School of Stomatology of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology The Affiliated Hospital of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery The Affiliated Hospital of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baodong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology The Affiliated Hospital of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-0079","authenticated-orcid":false,"given":"Yaping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology The Affiliated Hospital of Qingdao University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26516"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0859"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S164677"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128227"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.04.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802006000100006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.19712"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-017-0124-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29401"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2015.12.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23061"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.09.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3826"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0511-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201508102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.204453.112"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011033"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.058"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12705"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-4272-5_22"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020129"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00031"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.026"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0796-2"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S107101"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0543"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-010-9340-1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00265-1"},{"key":"e_1_2_10_34_1","first-page":"515","article-title":"Acetyl\u2010CoA carboxylase\u2010a as a novel target for cancer therapy","volume":"2","author":"Wang C","year":"2010","journal-title":"Front Biosci (Schol Ed)"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.020"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1489"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28415"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0585"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290905.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029761"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.374"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194801"},{"key":"e_1_2_10_45_1","first-page":"1","article-title":"Fisetin inhibits autophagy in HepG2 cells via PI3K\/Akt\/mTOR and AMPK pathway","volume":"21","author":"Sundarraj K","year":"2020","journal-title":"Nutr Cancer"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030582"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010193"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2059"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.04.016"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.237"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.13367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:44:01Z","timestamp":1693003441000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/2211-5463.13367"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13367","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"2020-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}