{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:41:18Z","timestamp":1790905278821,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20170412153155228"],"award-info":[{"award-number":["JCYJ20170412153155228"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    <jats:italic>Helicobacter\u2009pylori<\/jats:italic>\n                    infection is a prevalent infectious disease, associated with many gastric diseases, including gastritis, gastric ulcer, and gastric cancer. To reveal the characteristics of the gastric microbiome in patients infected with\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    , we performed metagenomic shotgun sequencing of stomach swab samples from 96 patients and then conducted metagenomic association analyses between alterations in the gastric microbiome and\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    infection status. The overall composition of the gastric microbiota in\n                    <jats:italic>H.\u2009pylori\u2010infected<\/jats:italic>\n                    individuals was distinctly different from the negative controls;\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    became the dominant species after colonizing the human stomach and significantly decreased the \u03b1\u2010diversity of the gastric community (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05, Wilcoxon rank\u2010sum test). We also identified 6 HPI\u2010associated microbial species (FDR\u2009&lt;\u20090.05, Wilcoxon rank\u2010sum test):\n                    <jats:italic>Stenotrophomonas\u2009maltophilia<\/jats:italic>\n                    ,\n                    <jats:italic>Stenotrophomonas<\/jats:italic>\n                    unclassified,\n                    <jats:italic>Chryseobacterium<\/jats:italic>\n                    unclassified,\n                    <jats:italic>Pedobacter<\/jats:italic>\n                    unclassified,\n                    <jats:italic>Variovorax<\/jats:italic>\n                    unclassified, and\n                    <jats:italic>Pseudomonas\u2009stutzeri<\/jats:italic>\n                    . Furthermore, 55 gastric microbial pathways were enriched in the\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    \u2010positive group, whereas only 2 pathways were more abundant in the\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    \u2010negative group: dTDP\u2010L\u2010rhamnose biosynthesis and tetrapyrrole biosynthesis (FDR\u2009&lt;\u20090.05, Wilcoxon rank\u2010sum test). Gastritis was not associated with non\u2010\n                    <jats:italic>H.\u2009pylori<\/jats:italic>\n                    species in the stomach (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05, Wilcoxon rank\u2010sum test). This study revealed alterations in gastric microbial taxa and function associated with HPI in the Chinese population, which provides an insight into gastric microbial interactions and their potential role in the pathological process of gastric diseases.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13390","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T03:53:46Z","timestamp":1646366026000},"page":"1188-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Helicobacter pylori<\/i>\n                    infection affects the human gastric microbiome, as revealed by metagenomic sequencing"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-8527","authenticated-orcid":false,"given":"Daoming","family":"Wang","sequence":"first","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen 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