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Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain, chronic low back pain, cancer pain induced by bone metastasis, and diabetic neuralgia. However, the clinical development of tanezumab has been terminated due to the risk of induction of rapidly progressive osteoarthritis (RPOA), and no other NGF antibodies have been examined for their ability to treat diabetic neuralgia in either animal models or clinical trials. In this study, a humanized high\u2010affinity NGF monoclonal antibody (mAb), huAb45 that could neutralize the interaction between NGF and its high\u2010affinity receptor TrkA. In a mouse diabetic neuralgia model, it effectively relieved neuropathic pain. 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