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Upon infection, cells recognize viral pathogen\u2010associated molecular patterns, activating the innate antiviral defenses. As such, during most of the replication cycle, the virus has to deal with the cellular antiviral response. At this point, it should not be forgotten that viruses are obligate intracellular parasites and thus are entirely dependent on the host cell for their replication. This dependency has pushed viruses to evolve unorthodox strategies to subvert and repurpose cellular factors and processes required for efficient replication. Even if a virus has the potential to be successful at each step necessary for its spread, this does not mean it has won the war against the host. Another threat to viruses is represented by antiviral drugs designed to diminish their survival and promote the host's wellbeing. This editorial outlines the contents of this special \u2018In the Limelight\u2019 issue of <jats:italic>FEBS Open Bio<\/jats:italic> focused on Virology. The section contains four review articles, each focused on a particular aspect of virus\u2013host interaction, including the antiviral response, subversion of the host translational machinery, repurposing of cellular factors, and the development of antiviral drugs.<\/jats:p>","DOI":"10.1002\/2211-5463.13420","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T09:49:42Z","timestamp":1654076982000},"page":"1094-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Host\u2013virus relationships: a sum of many battles"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-8478","authenticated-orcid":false,"given":"Marcelo","family":"L\u00f3pez\u2010Lastra","sequence":"first","affiliation":[{"name":"Laboratorio de Virolog\u00eda Molecular Departamento de Enfermedades Infecciosas e Inmunolog\u00eda Pedi\u00e1trica Instituto Milenio de Inmunolog\u00eda e Inmunoterapia Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Fields virology","author":"Knipe DM","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-092818-015756"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13382"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13060952"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14020188"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13400"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13419"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.10.004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13416"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0002-y"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/2211-5463.13420","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:36:21Z","timestamp":1692851781000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/2211-5463.13420"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13420","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2022-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}