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Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell\u2010permeating peptides a logical choice to address VL. Unfortunately, the limited biological stability of peptides restricts their usage. Sequence\u2010specific oligo\u2010<jats:italic>N<\/jats:italic>\u2010substituted glycines (\u2018peptoids\u2019) are a class of peptide mimics that offers an excellent alternative to peptides in terms of ease of synthesis and good biostability. We tested peptoids against the parasite <jats:italic>Leishmania donovani<\/jats:italic> in both forms, that is, intracellular amastigotes and promastigotes. <jats:italic>N<\/jats:italic>\u2010alkyl hydrophobic chain addition (lipidation) and bromination of oligopeptoids yielded compounds with good antileishmanial activity against both forms, showing the promise of these antiparasitic peptoids as potential drug candidates to treat VL.<\/jats:p>","DOI":"10.1002\/2211-5463.13562","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T07:29:54Z","timestamp":1674458994000},"page":"519-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Membrane\u2010acting biomimetic peptoids against visceral 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