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Recent studies suggested that the NLRP3 inflammasome could be a therapeutic target for cutaneous melanoma (CM), but the role of NLRP3 in UM remains unknown. Here, we analyzed the NLRP3\u2010IL\u20101\u03b2 axis in 5 UM and 4 CM cell lines. Expression of NLRP3 mRNA in UM and CM was low, and expression in UM was lower than in CM (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). NLRP3 protein levels were below detection limit for all cell lines. UM exhibited lower baseline IL\u20101\u03b2 secretion than CM, especially when compared to the Hs294t cell line (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Bioinformatic analysis of human tumor samples showed that UM has significantly lower expression of NLRP3 and IL\u20101\u03b2 compared with CM. In conclusion, our work shows evidence of extremely low NLRP3 expression and IL\u20101\u03b2 secretion by melanoma cells and highlight differences between CM and UM.<\/jats:p>","DOI":"10.1002\/2211-5463.13566","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T05:28:36Z","timestamp":1674883716000},"page":"545-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The <scp>NLRP3<\/scp> inflammasome \u2013 interleukin 1\u03b2 axis in uveal melanoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-7883","authenticated-orcid":false,"given":"Victor S. M. 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