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To identify possible biomarkers, here we examined changes in the expression of C\u2010telopeptide fragments of type II collagen (CTX\u2010II) and collagenase generated carboxy\u2010terminal neoepitope of type II collagen (C2C) in serum at different time points in an anterior cruciate ligament transection (ACLT)\u2010induced rat OA model. The serum levels of CTX\u2010II and C2C, and the OARSI score in the ACLT group were increased from week two until the end of the experiment. The AUC of the combined biomarkers was higher than that of CTX\u2010II or C2C alone. Moreover, serum levels of CTX\u2010II and C2C were positively correlated with the OARSI score. The results suggest that the combined detection of serum CTX\u2010II and C2C concentrations may have potential for assessing and diagnosing OA at early stages.<\/jats:p>","DOI":"10.1002\/2211-5463.13613","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T18:04:00Z","timestamp":1681668240000},"page":"1485-1494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined detection of serum <scp>CTX\u2010II<\/scp> and <scp>C2C<\/scp> in a rat model of <scp>ACLT<\/scp>\u2010induced osteoarthritis"],"prefix":"10.1002","volume":"13","author":[{"given":"Fei","family":"Yu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Northeast Agricultural University  Harbin China"},{"name":"Heilongjiang Key Laboratory of Animals Disease Pathogenesis and Comparative Medicine  Harbin 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