{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:46:37Z","timestamp":1782931597234,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Previous studies have revealed that age\u2010related hearing loss (AHL) in Cdk5 regulatory subunit\u2010associated protein 1 (\n                    <jats:italic>Cdk5rap1<\/jats:italic>\n                    )\u2010knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of\n                    <jats:italic>Cdk5rap1<\/jats:italic>\n                    \u2010knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis. Our results suggest that the accumulation of dysfunctional mitochondria in the lateral wall, rather than the loss of HCs and SGNs, leads to the onset of AHL. Our results provide valuable information regarding the underlying mechanisms of AHL and the relationship between aberrant tRNA modification\u2010induced hearing loss and mitochondrial dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13655","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T22:25:43Z","timestamp":1685571943000},"page":"1365-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mitochondrial alterations in the cochlea of\n                    <i>Cdk5rap1<\/i>\n                    \u2010knockout mice with age\u2010related hearing loss"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-0056","authenticated-orcid":false,"given":"Toru","family":"Miwa","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Graduate School of Medicine Kyoto University  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