{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:04Z","timestamp":1772117824586,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Wolfram syndrome is a monogenic disease mainly caused by mutations in the\n                    <jats:italic>WFS1<\/jats:italic>\n                    gene. Mutations in the\n                    <jats:italic>WFS1<\/jats:italic>\n                    gene give rise to diabetes. Here, we characterized mutant WFS1 proteins by studying the stability of full\u2010length wild\u2010type (WT) WFS1, a missense mutant P724L, and two C\u2010terminally truncated mutants, W837X and Y652X. We compared their stability by overexpressing them in MIN6 and HEK293T cells. The C\u2010terminally truncated mutants W837X and Y652X are degraded more rapidly than the missense P724L mutant or wild\u2010type WFS1 in MIN6 cells. In contrast, Y652X is more stable than WT or other mutant WFS1 proteins in HEK293T. In conclusion, we found that C\u2010terminally truncated WFS1 mutants are selectively degraded in a cell type\u2010specific manner.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13674","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T13:54:22Z","timestamp":1689256462000},"page":"1405-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective proteasome degradation of C\u2010terminally\u2010truncated human\n                    <scp>WFS1<\/scp>\n                    in pancreatic beta cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Hiraku","family":"Tokuma","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Tokyo Institute of Technology  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Sakano","sequence":"additional","affiliation":[{"name":"School of Life Science and 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