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Previous studies have shown that EGCG induces cancer\u2010specific cell death\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    without causing severe side effects. However, the anti\u2010cancer effect of EGCG alone is limited. 5,7\u2010dimethoxyflavone (5,7\u2010DMF), one of the principal functional components of black ginger (\n                    <jats:italic>Kaempferia parviflora<\/jats:italic>\n                    ), also exerts anti\u2010cancer effects. Here, we show that 5,7\u2010DMF synergistically enhances the anti\u2010cancer effect of EGCG in multiple myeloma cells by potentiating EGCG\u2010induced intracellular cyclic guanosine monophosphate (cGMP) production. Moreover, the combination of EGCG and 5,7\u2010DMF induces apoptotic cell death in multiple myeloma cells, and this is accompanied by activation of the cGMP\/acid sphingomyelinase (ASM)\/cleaved caspase\u20103 pathway. In conclusion, we have shown that 5,7\u2010DMF enhances the anti\u2010cancer effect of EGCG by upregulating cGMP in multiple myeloma cells.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13708","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T22:08:56Z","timestamp":1695247736000},"page":"2147-2156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The anti\u2010cancer effect of\n                    <scp>epigallocatechin\u20103\u2010<\/scp>\n                    <i>O<\/i>\n                    \u2010gallate against multiple myeloma cells is potentiated by 5,7\u2010dimethoxyflavone"],"prefix":"10.1002","volume":"13","author":[{"given":"Jaehoon","family":"Bae","sequence":"first","affiliation":[{"name":"Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture Kyushu University  Fukuoka Japan"},{"name":"Functional Biomaterial 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