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Excessive platelet\u2010leukocyte aggregate (PLA) formation promotes neutrophil extracellular trap (NET) release and thrombosis, which are involved in various diseases, including ALI. Macrophage\u20101 antigen (Mac\u20101, CD11b\/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac\u20101 in extracellular histone\u2010induced ALI. Exogenous histones were administered to Mac\u20101\u2010deficient mice and wild\u2010type (WT) mice with or without neutrophil or platelet depletion, and several parameters were investigated 1\u2009h after histone injection. Depletion of neutrophils or platelets improved survival time and macroscopic and microscopic properties of lung tissues, and decreased platelet\u2010leukocyte formation and plasma myeloperoxidase levels. These improvements were also observed in Mac\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. NET formation in Mac\u20101\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    bone marrow neutrophils (BMNs) was significantly lower than that in WT BMNs. In conclusion, our findings suggest that Mac\u20101 is associated with exacerbation of histone\u2010induced ALI and the promotion of NET formation in the presence of activated platelets.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13779","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T21:19:20Z","timestamp":1708031960000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Macrophage\u20101 antigen exacerbates histone\u2010induced acute lung injury and promotes neutrophil extracellular trap formation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-392X","authenticated-orcid":false,"given":"Tomohiro","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapeutics and Informatics Fujita Health University School of Medicine  Toyoake 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