{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:02:23Z","timestamp":1793131343020,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Oleanolic acid (OA) is a pentacyclic triterpene with reported protective effects against various diseases, including diabetes, hepatitis, and different cancers. However, the effects of OA on obesity\u2010induced muscle atrophy remain largely unknown. This study investigated the effects of OA on skeletal muscle production and proliferation of C2C12 cells. We report that OA significantly increased skeletal muscle mass and improved glucose intolerance and insulin resistance. OA inhibited dexamethasone (Dex)\u2010induced muscle atrophy in C2C12 myoblasts by regulating the PI3K\/Akt signaling pathway. In addition, it also inhibited expression of\n                    <jats:italic>MuRF1<\/jats:italic>\n                    and\n                    <jats:italic>Atrogin1<\/jats:italic>\n                    genes in skeletal muscle of obese mice suffering from muscle atrophy, and increased the activation of PI3K and Akt, thereby promoting protein synthesis, and eventually alleviating muscle atrophy. Taken together, these findings suggest OA may have potential for the prevention and treatment of muscle atrophy.\n                  <\/jats:p>","DOI":"10.1002\/2211-5463.13780","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T03:31:04Z","timestamp":1708140664000},"page":"584-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oleanolic acid alleviates obesity\u2010induced skeletal muscle atrophy via the\n                    <scp>PI3K<\/scp>\n                    \/Akt signaling pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Yaqin","family":"Sun","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxing","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyun","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomao","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-0600","authenticated-orcid":false,"given":"Haidong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Shanxi Agricultural University  Jinzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.03.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13350"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01131-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0528"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b05387"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.06.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0062-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.06.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9523-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153696"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0286-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04752.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4467"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-017-3749-z"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2017.6406"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2011.11.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666191105112802"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-098"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.10.020"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.06.025"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24020340"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020226"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.697483"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.02.028"},{"key":"e_1_2_10_27_1","article-title":"Obesity augments glucocorticoid\u2010dependent muscle atrophy in male C57BL\/6J mice","volume":"8","author":"Gunder LC","year":"2020","journal-title":"Biomedicine"},{"key":"e_1_2_10_28_1","first-page":"22719","article-title":"Gonadal white adipose tissue\u2010derived exosomal MiR\u2010222 promotes obesity\u2010associated insulin resistance","volume":"12","author":"Li D","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314607"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.035"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109752"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113406"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32905-w"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104854"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506778"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.09.008"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-015-9626-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.054189"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00371"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/476279"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155158"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16448"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12253"},{"key":"e_1_2_10_44_1","first-page":"809","article-title":"The interplay between muscle mass decline, obesity, and type 2 diabetes","volume":"129","author":"Maliszewska K","year":"2019","journal-title":"Pol Arch Intern Med"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172612"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114625"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh058"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01970.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20112024"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12402"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112944"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.001222"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:13:44Z","timestamp":1712124824000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/2211-5463.13780"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13780","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/2211-5463.13780\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,17]]},"assertion":[{"value":"2023-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}