{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:54:05Z","timestamp":1790610845889,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Open Bio"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Alzheimer's disease (AD) is an increasingly important public health concern due to the increasing proportion of older individuals within the general population. The impairment of processes responsible for adequate brain energy supply primarily determines the early features of the aging process. Restricting brain energy supply results in brain hypometabolism prior to clinical symptoms and is anatomically and functionally associated with cognitive impairment. The present study investigated changes in metabolic profiles induced by intracerebroventricular\u2010streptozotocin (ICV\u2010STZ) in an AD\u2010like animal model. To this end, male Wistar rats received a single injection of STZ (3\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) by ICV (2.5\u2009\u03bcL into each ventricle for 5\u2009min on each side). In the second week after receiving ICV\u2010STZ, rats were tested for cognitive performance using the Morris Water Maze test and subsequently prepared for positron emission tomography (PET) to confirm AD\u2010like symptoms. Tandem Mass Spectrometry (MS\/MS) analysis was used to detect amino acid changes in cerebrospinal fluid (CFS) samples. Our metabolomics study revealed a reduction in the concentrations of various amino acids (alanine, arginine, aspartic acid, glutamic acid, glycine, isoleucine, methionine, phenylalanine, proline, serine, threonine, tryptophane, tyrosine, and valine) in CSF of ICV\u2010STZ\u2010treated animals as compared to controls rats. The results of the current study indicate amino acid levels could potentially be considered targets of nutritional and\/or pharmacological interventions to interfere with AD progression.<\/jats:p>","DOI":"10.1002\/2211-5463.13814","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:50:07Z","timestamp":1716259807000},"page":"1116-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>CSF<\/scp> amino acid profiles in <scp>ICV<\/scp>\u2010streptozotocin\u2010induced sporadic Alzheimer's disease in male Wistar rat: a metabolomics and systems biology perspective"],"prefix":"10.1002","volume":"14","author":[{"given":"Amir","family":"Barzegar Behrooz","sequence":"first","affiliation":[{"name":"Electrophysiology Research Center, Neuroscience Institute Tehran University of Medical Sciences  Iran"},{"name":"Department of Human Anatomy and Cell Science, College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-2682","authenticated-orcid":false,"given":"Hamid","family":"Latifi\u2010Navid","sequence":"additional","affiliation":[{"name":"Electrophysiology Research Center, Neuroscience Institute Tehran University of Medical Sciences  Iran"},{"name":"Department of Molecular Medicine National Institute of Genetic Engineering and Biotechnology  Tehran Iran"},{"name":"School of Biological Sciences Institute for Research in Fundamental Sciences (IPM)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabar","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Growth and Development Research Center Tehran University of Medical Sciences  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Khodagholi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Shojaei","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-508X","authenticated-orcid":false,"given":"Saeid","family":"Ghavami","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, College of Medicine University of Manitoba  Winnipeg Canada"},{"name":"Faculty of Medicine in Zabrze University of Technology in Katowice  Zabrze Poland"},{"name":"Research Institute of Oncology and Hematology Cancer Care Manitoba\u2010University of Manitoba  Winnipeg Canada"},{"name":"Children Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Fahanik Babaei","sequence":"additional","affiliation":[{"name":"Electrophysiology Research Center, Neuroscience Institute Tehran University of Medical Sciences  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054960"},{"key":"e_1_2_11_4_1","first-page":"1","volume-title":"Alzheimer's Disease","author":"Polis B","year":"2019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8375-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310040006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.06.019"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-9983-6"},{"key":"e_1_2_11_11_1","first-page":"217","article-title":"Central insulin resistance as a trigger for sporadic Alzheimer\u2010like pathology: an experimental approach","volume":"72","author":"Salkovic\u2010Petrisic M","year":"2007","journal-title":"J Neural Transm Suppl"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00235"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.15212\/AMM-2023-0001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5472792"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.10.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7704-8_3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101987"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5336273"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-021-01828-w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.07.006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.003"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-019-02705-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01569-3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.020"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031501"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.06.004"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.05.009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.11.035"},{"key":"e_1_2_11_30_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2006"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1073369"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2022.100095"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.12.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1762662"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","unstructured":"RosaSCS AlizadehJ VitorinoR SurendranA RavandiA KidaneBandGhavamiS(2024)A Lipidomics approach to determine the role of lipids and its crosstalk with autophagy in lung cancer metastasis.bioRxiv. doi:10.1101\/2024.01.01.573842","DOI":"10.1101\/2024.01.01.573842"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218154"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00425"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.3.479"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1051\/ocl\/2018044"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0169-8"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212158"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000245747.53008.e2"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.12.005"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.530219"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2005-7106"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02252924"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1219718"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.6.1539S"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.092"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8447-1"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12095"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150610125856"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1179\/174329210X12650506623645"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.2165\/11590190-000000000-00000"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-013-1583-0"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210461"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1289-9"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr5000895"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.03.001"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033177"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2016.0106"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom6020016"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01989-w"},{"key":"e_1_2_11_65_1","first-page":"5","article-title":"Protective effects of proline\u2010rich peptide in a rat model of Alzheimer disease: an electrophysiological study","volume":"8","author":"Khalaji N","year":"2017","journal-title":"Basic Clin Neurosci"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.754032"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.52"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091872"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0057-0"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4626"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.003"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.000869"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.10.007"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00243"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2019.09.002"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1161850"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0411-8"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.10.009"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00441"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00439"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-023-00364-y"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.08.018"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-46"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X21996176"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9132-3"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.160076"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.148175"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1064"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72755-4"}],"container-title":["FEBS Open Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.13814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:31:25Z","timestamp":1744360285000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/2211-5463.13814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":89,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/2211-5463.13814"],"URL":"https:\/\/doi.org\/10.1002\/2211-5463.13814","archive":["Portico"],"relation":{},"ISSN":["2211-5463","2211-5463"],"issn-type":[{"value":"2211-5463","type":"print"},{"value":"2211-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2024-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}