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The progression of the disease is rapid, and treatment must be initiated early to achieve cancer remission and extend life. This study examined the relationship between progression\u2010free survival (PFS) and microRNA (miRNA) expression in dogs with DLBCL. miRNAs are small non\u2010coding RNA molecules that typically regulate gene expression post\u2010transcriptionally. They are involved in several pathophysiological processes, including the growth and progression of cancer. Based on the analysis of small RNA sequencing (sRNA\u2010seq) data, we validated a group of miRNAs in lymph nodes from 44 DLBCL\u2010affected dogs with known outcomes. We used quantitative PCR to quantify their expression and report a specific subset of miRNAs is associated with decreased PFS in dogs with DLBCL. The miR\u2010192\u20105p and miR\u201016\u20105p expression were significantly downregulated in dogs with increased PFS. 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Identifying specific miRNAs that correlate with the progression of canine DLBCL could aid the development of individualized treatment regimens for dogs.<\/jats:p>","DOI":"10.1002\/2211-5463.13887","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T21:18:50Z","timestamp":1725225530000},"page":"1899-1913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Micro\n                    <scp>RNA<\/scp>\n                    s implicated in canine diffuse large B\u2010cell lymphoma prognosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4726-8584","authenticated-orcid":false,"given":"Nelly O.","family":"Elshafie","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology Purdue University  West Lafayette IN 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